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Pertpy: an end-to-end framework for perturbation analysis
1 day ago
Nature Methods, Published online: 31 December 2025; doi:10.1038/s41592-025-02909-7Pertpy serves as a one-stop...
The missing data for intelligent scientific instruments
1 day ago
Nature Methods, Published online: 31 December 2025; doi:10.1038/s41592-025-02995-7Most scientific instruments currently discard...
AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging
1 day ago
Nature Methods, Published online: 31 December 2025; doi:10.1038/s41592-025-02871-4This Review provides a comprehensive...
Whole-brain phenotype mapping between humans and mice
1 day ago
Nature Methods, Published online: 31 December 2025; doi:10.1038/s41592-025-02963-1We introduce TransBrain, a computational...
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases
1 day ago
Nature Methods, Published online: 31 December 2025; doi:10.1038/s41592-025-02969-9SpatialZ generates virtual single-cell spatial...
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions
1 day ago
Nature Methods, Published online: 31 December 2025; doi:10.1038/s41592-025-02919-5cellSTAAR advances noncoding rare variant...
AI-guided electron microscopy accelerates brain mapping
2 days ago
Nature Methods, Published online: 30 December 2025; doi:10.1038/s41592-025-02930-wWe developed SmartEM, a method...
The jellyfish Clytia hemisphaerica
3 days ago
Nature Methods, Published online: 30 December 2025; doi:10.1038/s41592-025-02993-9The jellyfish Clytia hemisphaerica has...
Guidance for 3D traction force microscopy today and in the next decade
4 days ago
Nature Methods, Published online: 29 December 2025; doi:10.1038/s41592-025-02934-6This Perspective envisions the future...
SmartEM: machine learning-guided electron microscopy
4 days ago
Nature Methods, Published online: 29 December 2025; doi:10.1038/s41592-025-02929-3SmartEM is a ‘smart’ pipeline...
TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice
4 days ago
Nature Methods, Published online: 29 December 2025; doi:10.1038/s41592-025-02961-3TransBrain translates brain phenotypes between...
Tissue maps in motion
9 days ago
Nature Methods, Published online: 24 December 2025; doi:10.1038/s41592-025-02950-6DynamicAtlas is a new open-source...