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Last updated 10 days ago
Symbiotic entrenchment through ecological Catch-22
10 days ago
A symbiotic rove beetle develops a stealth phenotype by silencing production of...
A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor
10 days ago
Engineered repressible promoters enable tunable fluorescence outputs in Bacteroides and the development...
A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration
10 days ago
The pentose phosphate pathway plays a dual role in enabling homeostatic and...
Structure of pancreatic hIAPP fibrils derived from patients with type 2 diabetes
10 days ago
Cryo-EM structures of hIAPP fibrils extracted from the surgically excised pancreases of...
Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex
10 days ago
This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal...
Metabolically regulated proteasome supramolecular organization in situ
10 days ago
Structural steps along the assembly of proteasome storage granules—membraneless organelles that form...
Continuum architecture dynamics of vesicle tethering in exocytosis
10 days ago
Data from complementary imaging techniques were integrated into a model that resolves...
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
10 days ago
Structural and functional analyses elucidate the mechanisms by which two ATP-independent RNA...
An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery
10 days ago
Organ-level localized delivery is a long-standing challenge, especially for gene therapy. This...
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo
10 days ago
Supramolecular targeting chimeras (SupTACs) are a modular and programmable platform that enables...
A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis
10 days ago
The RFC clamp loader remains associated with PCNA beyond the loading step...
Field-effect-informed urine liquid biopsy for bladder cancer
10 days ago
By removing the noise from mutations in tumor-adjacent normal tissue, the field-effect-informed...