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Last updated 9 days ago
Biodiversity and biogeography of the multi-kingdom cancer microbiome
9 days ago
A host-filtering and decontamination pipeline was benchmarked and applied to 16,369 tumor...
Single-cell mapping of regulatory DNA-protein interactions
9 days ago
D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to...
RegVelo: Gene-regulatory-informed dynamics of single cells
9 days ago
RegVelo introduces an end-to-end generative framework that jointly infers gene regulatory networks...
The evolution of high-order genome architecture revealed from 1,000 species
9 days ago
Comparative Hi-C analysis across 1,025 species reveals that genome architecture has evolved...
Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles
9 days ago
CRISPR perturbation of ∼4 million gene pairs in human HAP1 cells maps...
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
9 days ago
Cancer-associated somatic variants are enriched in the brain immune cells of Alzheimer’s...
A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer
9 days ago
Breast cancer macrometastases expand by activating a metastatic trabecular morphogenesis (MTM) program...
Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse
9 days ago
Donor-derived CD8⁺ CAR TSCM cells exhibit enhanced expansion and a favorable safety...
Sulfur partitioning from cysteine controls T cell proliferation and effector function
9 days ago
This study pinpoints cysteine’s sulfur as a key determinant of CD8+ T...
Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells
9 days ago
Genome-wide CRISPR activation and knockout screens in primary human CD4+ T cells...
2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity
9 days ago
An evolutionarily conserved CBASS transmembrane effector—ancestral to the mammalian cGAS-STING pathway—is activated...
A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes
9 days ago
This study provides a paradigm for how the vast chemical diversity inherent...