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Last updated 11 days ago
Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK
11 days ago
The cryo-electron microscopy structure of the bridge-like lipid-transfer protein VPS13A in complex...
Plant cell wall-plasma membrane attachments mediate stress resilience through cellulose synthase complexes and remorins
11 days ago
In plants, cell wall-plasma membrane attachments become evident upon severe water loss...
Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation
11 days ago
By acquiring an energy metabolism-related gene via ancient horizontal transfer from a...
Xenophagocytosis blockade enhances interspecies chimerism
11 days ago
Host macrophages limit interspecies chimerism via xenophagocytosis, whereby stressed donor cells expose...
Shared neural geometries for bilingual semantic representations in human hippocampal neurons
11 days ago
In bilinguals, hippocampal recordings during listening and speaking revealed overlapping neural geometry...
An emergent disease-associated motor neuron state precedes cell death in ALS
11 days ago
Longitudinal multi-omics in SOD1-ALS mice identifies a disease-associated motor neuron (DM) state...
Nuclear proteome reveals microtubule-associated protein regulating fate and disease
11 days ago
Nuclear and cytoplasmic proteomics uncover a nuclear pool of cytoskeletal proteins, including...
Iron drives protease-independent cleavage of gasdermin D in allergic airway diseases
11 days ago
Allergen exposure activates gasdermin D in lung epithelial cells through an iron-mediated...
Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system
11 days ago
Bacterial reverse transcriptases defend against viruses, yet how their DNA products stop...
Replaying germinal center evolution on a quantified affinity landscape
11 days ago
Antibody affinity maturation results from a somatic evolutionary process that takes place...
Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer
11 days ago
Protein language models have excelled at modeling individual proteins, but extending these...
UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling
11 days ago
UniPert-G2CP is an AI framework for jointly modeling molecular-level perturbation causes with...