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Last updated 6 days ago
Breathing new life into the rational design of Alzheimer’s therapeutics
6 days ago
(Cell 184, 296-298; January 21, 2021)
Genomics and social practices at Mogou and other Gansu sites during prehistoric trans-Eurasian exchange
6 days ago
Ancient DNA from 149 individuals at 11 sites in Gansu, China, dated...
Reconstituting human primitive streak formation through extra-embryonic cell coordination
6 days ago
Tissue patterning events of early human embryo development, including an embryo-disc with...
Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders
6 days ago
Single-cell whole-genome sequencing reveals a shared pattern of excessive somatic mutations across...
Localized PD-1 CAR T therapy reprograms neuroinflammation
6 days ago
PD-1+ T follicular helper-like cells drive B cell-associated pathology in multiple sclerosis...
CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics
6 days ago
Cerebrospinal fluid (CSF) crosses arachnoid fenestrations near the olfactory bulbs to reach...
Skin-innervating glutamatergic neurons modulate aging
6 days ago
Within the skin, glutamatergic neurons expressing neurofilament heavy chain (Nefh) play a...
Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
6 days ago
By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist...
Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine
6 days ago
Complete biosynthetic pathways for cephalotaxinone and homoerythratine were elucidated from the endangered...
Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis
6 days ago
A deep-tissue spatial transcriptomics method simultaneously captures hundreds of hair follicles spanning...
Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs
6 days ago
Corals harbor intracellular algal symbionts in specialized organelles that enable them to...