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Last updated 9 days ago

IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion

9 days ago

IRGQ acts in the quality control of MHC class I molecules through...

IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer

9 days ago

Mechanisms dictating the form of chemotherapy-induced cancer cell death are elusive. This...

Identifying specific functional roles for senescence across cell types

9 days ago

A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene...

Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer

9 days ago

An image analysis pipeline that integrates cell-state and morphological markers identifies clinically...

Multiscale organization of neuronal activity unifies scale-dependent theories of brain function

9 days ago

Analysis of cellular recordings from five phylogenetically diverse species uncovers a conserved...

Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques

9 days ago

A two-step approach against HIV can reproducibly generate a potent plasma repertoire...

Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

9 days ago

A multiscale drug discovery platform integrating human induced pluripotent stem cells, 3D-engineered...

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification

9 days ago

A monoclonal antibody VIR-7229 uniquely combines potent SARS-CoV-2 inhibition via ACE2 competition...

The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity

9 days ago

Cad1 is an hexameric type III CRISPR-CARF effector harboring an adenosine deaminase...

Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer

9 days ago

Single-molecule spatial imaging in human pancreatic cancers identifies aberrant repeat RNA expression...

Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch

9 days ago

Bile acids (BAs) are 3-sulfonated to improve their potency to activate MRGPRX4...