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Last updated 12 days ago
Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage
12 days ago
A Yersinia pestis genome from a Bronze Age domesticated sheep provides insight...
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
12 days ago
A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid...
Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers
12 days ago
Large-scale analysis of phase 3 trial samples reveals novel biomarker-treatment pairings to...
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL
12 days ago
While targeting glucose metabolism shows potential in cancer therapy, its clinical implications...
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
12 days ago
PPARγ downregulation in colonic CD8+ T cells from people with HIV (PWH)...
DNA mutagenesis driven by transcription factor competition with mismatch repair
12 days ago
Competition between transcription factors and mismatch repair machinery drives localized hypermutation at...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
12 days ago
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which...
Regulation of inflammatory responses by pH-dependent transcriptional condensates
12 days ago
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically...
Highly conserved Betacoronavirus sequences are broadly recognized by human T cells
12 days ago
Combining spike and conserved regions of non-spike proteins from Betacoronaviruses in vaccination...
Principles of cotranslational mitochondrial protein import
12 days ago
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human...
Replisome passage through the cohesin ring
12 days ago
Glaser et al. use single-molecule imaging to visualize encounters between the DNA-replication...
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1
12 days ago
Structures of the solute carrier transporters MCT8 and OATP1C1 reveal mechanisms of...