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Last updated 21 days ago
Synthesis of medicinally relevant oxalylamines via copper/Lewis acid synergistic catalysis
21 days ago
Allylamines have long been recognized as valuable synthons because of their excellent...
Multiform antimicrobial resistance from a metabolic mutation
21 days ago
A critical challenge for microbiology and medicine is how to cure infections...
No ordinary proteins: Adsorption and molecular orientation of monoclonal antibodies
21 days ago
The interaction of monoclonal antibodies (mAbs) with air/water interfaces plays a crucial...
High-purity production and precise editing of DNA base editing ribonucleoproteins
21 days ago
Ribonucleoprotein (RNP) complex–mediated base editing is expected to be greatly beneficial because...
Environmental vulnerability of the global ocean epipelagic plankton community interactome
21 days ago
Marine plankton form complex communities of interacting organisms at the base of...
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation
21 days ago
Nonhealing diabetic wounds are common complications for diabetic patients. Because chronic hypoxia...
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization
21 days ago
Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting coactivators and...
Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage
21 days ago
Double-strand breaks (DSBs) are harmful lesions and a major cause of genome...
Basal nucleation and the prevalence of ascending swarms in Long Valley caldera
21 days ago
Earthquake swarms are ubiquitous in volcanic systems, being manifestations of underlying nontectonic...
Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors
21 days ago
The metabolic mechanisms involved in the survival of tumor cells within the...
Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis
21 days ago
Body temperature homeostasis is essential and reliant upon the integration of outputs...
An epigenetic basis of inbreeding depression in maize
21 days ago
Inbreeding depression is widespread across plant and animal kingdoms and may arise...