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TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia | Science Advances

1 day ago

Abstract Oncogenic fusion transcription factors (TFs) frequently drive hematopoietic malignancies by altering...

Internally promoted reactivity of carbonized butadiene and amines enables a recyclable polymer composite | Science Advances

about 8 hours ago

Abstract The catalytic conversion of carbon dioxide into polymers via high-energy comonomers...

Powering Ganymede’s dynamo with protracted core formation | Science Advances

about 8 hours ago

Abstract Ganymede is the only known moon with an active dynamo today....

Chemical stimulation sustains bioluminescence of living light materials | Science Advances

about 8 hours ago

Abstract Bioluminescence offers a powerful tool for real-time, label-free sensing for living...

Tunable TriPcides suppress virulence factor secretion during Staphylococcus aureus infection and kill dormant cells | Science Advances

about 8 hours ago

Abstract Antimicrobial resistance (AMR) in common bacterial pathogens, including methicillin-resistant Staphylococcus aureus...

A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation | Science Advances

about 8 hours ago

Abstract Accurate chromosome segregation requires dynamic kinetochore-microtubule attachments that, under the regulation...

Decadal East Asian monsoon anomalies and implications for societal conflicts | Science Advances

about 8 hours ago

Abstract The East Asian summer monsoon anomalies, responsible for floods and droughts...

Optical corner detection with azimuthal Hilbert transform metasurfaces | Science Advances

about 8 hours ago

Abstract Many animals efficiently interpret their environment by detecting geometric features like...

ATRA improves megakaryopoiesis in immune thrombocytopenia through up-regulating the HIF-1α/SPHK2/S1P pathway | Science Advances

about 8 hours ago

Abstract Our previous clinical studies show that all-trans retinoic acid (ATRA) induces...

Elastic rod origami (RodOri) for programming static and dynamic mechanical properties | Science Advances

about 8 hours ago

Abstract Reconfigurable mechanical systems enable precise programmable control over structural properties, expanding...

Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch–triggered calorie reduction | Science Advances

about 8 hours ago

Abstract Insulin resistance (IR) links obesity to metabolic disorders. While weight loss...

Super-stable two-dimensional radical conjugated metal-organic frameworks for efficient NIR-II photothermal conversion | Science Advances

about 8 hours ago

Abstract Radical-functionalized chromophores hold promise as noninvasive NIR-II agents due to their...