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Last updated about 3 hours ago
Sensitive detection of structural dynamics using a statistical framework for comparative crystallography | Science Advances
about 3 hours ago
Abstract Chemical and conformational changes are crucial to protein function and its...
VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation | Science Advances
about 3 hours ago
Abstract Memory consolidation enables animals to draw on past experiences to guide...
Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology | Science Advances
about 3 hours ago
Abstract Biomolecular condensates mediate dynamic compartmentalization of cellular processes. The multivalent interactions...
B cell–reactive neoantigens boost antitumor immunity | Science Advances
about 3 hours ago
Abstract B cell involvement in neoantigen-driven antitumor immunity remains largely unexplored because...
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease | Science Advances
about 3 hours ago
Abstract In the later stages of Parkinson’s disease, patients often manifest levodopa-induced...
VAPB is a negative regulator of STING-mediated innate immune signaling | Science Advances
about 3 hours ago
Abstract Stimulator of IFN genes (STING) is an endoplasmic reticulum (ER) signaling...
Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation | Science Advances
about 3 hours ago
Abstract The specification of intestinal stem cells (ISCs) during development is critical...
Asymmetric synthesis of chiral boronic esters featuring nonadjacent axial and flexible, acyclic central chirality | Science Advances
about 3 hours ago
Abstract Nonadjacent chirality is prevalent in pharmaceuticals and bioactive molecules, but prior...
An ultrasmall theranostic nanozyme for abdominal aortic aneurysm management and therapeutic efficacy monitoring | Science Advances
about 3 hours ago
Abstract Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective drug...
Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation | Science Advances
about 3 hours ago
Abstract Carcinogenesis in human urothelium is driven by a high burden of...
Quantum-inspired computational wavefront shaping enables turbulence-resilient distributed aperture synthesis imaging | Science Advances
about 3 hours ago
Abstract Wavefront shaping is essential for optical imaging through aberrations, but conventional...
Achieving cysteine-selective peptide/protein bioconjugation via tunable triazine-pyridine chemistry | Science Advances
about 3 hours ago
Abstract The development of cysteine (Cys)–selective bioconjugation reagents with enhanced stability remains...