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A synthetic Antrodia cinnamomea galactomannan library by frameshift unveils a potent immunoregulatory octasaccharide domain | Science Advances
1 day ago
Abstract We report the design, synthesis, and immunological evaluation of an Antrodia...
The root nodule symbiosis regulator NIN exhibits broad DNA binding specificity conferred by an NLP-inherited motif | Science Advances
1 day ago
Abstract Nitrogen-fixing root nodule symbiosis (RNS) occurs in some eudicots, including legumes,...
Pyruvate kinase muscle 2 (PKM2) promotes CD4 T cell survival by regulating pyruvate oxidation during homeostasis and expansion | Science Advances
1 day ago
Abstract Glycolysis is an essential metabolic pathway for rapidly expanding T cells,...
The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events | Science Advances
1 day ago
Abstract Reward processes have traditionally been ascribed to dopamine (DA)–associated circuits. While...
Eccentricity rhythms in the Oligocene-Miocene carbon cycle regulated by weathering and carbonate burial | Science Advances
1 day ago
Abstract During the Cenozoic unipolar ice ages, benthic foraminiferal oxygen and carbon...
Monitoring glioblastoma extracellular vesicle evolution using a nanodiagnostic platform to detect glioma stem cells driving recurrent disease | Science Advances
1 day ago
Abstract Assessing therapeutic response in glioblastoma (GBM) is a major factor limiting...
Structural insight into the glucose-6-phosphate transport by G6PT1 and inhibition mechanism of CGA | Science Advances
1 day ago
Abstract Human glucose-6-phosphate transporter 1 (G6PT1) is responsible for transporting glucose-6-phosphate (G6P)...
Cryo-EM structure of human AQP11 reveals a trimeric architecture with a large pore | Science Advances
1 day ago
Abstract Aquaporin-11 (AQP-11) is an endoplasmic reticulum-localized water channel essential for renal...
An electrophilicity-engineered magnetic sensor for MRI detection of dormant tumor cell clusters | Science Advances
1 day ago
Abstract In magnetic resonance imaging (MRI), direct dipole-dipole interactions between paramagnetic metal...
Quantum state revival via coherent energy redistribution | Science Advances
1 day ago
Abstract Processing and detecting quantum states with high fidelity are essential for...
Induction of collective behavior by β-1,3-glucans in microalgae | Science Advances
1 day ago
Abstract β-1,3-glucans are multifaceted molecules, playing a key role in aquatic ecosystems...
Computational rational design of unspecific peroxygenase for C-H oxidation | Science Advances
1 day ago
Abstract Computational rational design has emerged as a transformative approach to engineer...