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Last updated 4 days ago
Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling | Science Translational Medicine
4 days ago
Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages...
Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury | Science Translational Medicine
4 days ago
Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.
A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice | Science Translational Medicine
4 days ago
A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies...
Locking down IgE | Science Translational Medicine
4 days ago
A vaccine candidate induces antibodies that inhibit the ability of IgE antibodies...
Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD | Science Translational Medicine
4 days ago
Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune...
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease | Science Translational Medicine
4 days ago
PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and...
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis | Science Translational Medicine
4 days ago
IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in...
A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis | Science Translational Medicine
11 days ago
Rapid gene expression changes during treatment of neonatal sepsis indicate reversibility of...
An early clinical trial of 5-ALA sonodynamic therapy in recurrent high-grade glioma | Science Translational Medicine
11 days ago
An early clinical study demonstrates feasibility of noninvasive 5-ALA sonodynamic treatment in...
Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses | Science Translational Medicine
11 days ago
A multipathogen population serological study enabled inference of the antigenic landscape of...
Failure of nerve regeneration in mouse models of diabetes is caused by p35-mediated CDK5 hyperactivity | Science Translational Medicine
11 days ago
Mouse and cell models suggest that GSK3β and the p35-CDK5-CRMP2 axis are...
Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice | Science Translational Medicine
11 days ago
Lymphotoxin alpha represses acute myeloid leukemia by depleting TRAF2 and triggering cell...