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Last updated about 8 hours ago
PD-1–targeted cis-delivery of an IL-2 variant induces a multifaceted antitumoral T cell response in human lung cancer | Science Translational Medicine
about 8 hours ago
Human intratumoral T cells treated with PD1-IL2v up-regulate chemotactic and effector molecules...
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | Science Translational Medicine
about 8 hours ago
Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants...
A complete Sigmodon hispidus genome and dynamic single-cell transcriptomics reveal evolutionarily conserved responses to RSV infection | Science Translational Medicine
about 8 hours ago
Cotton rats replicate human RSV infection at the genomic and single-cell level...
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles | Science Translational Medicine
about 8 hours ago
Sex-specific differences in immune selection of HIV-1 reservoir cells during long-term antiretroviral...
Hippocampal spreading depolarization as a driver of postictal ambulation | Science Translational Medicine
about 8 hours ago
Seizure-associated spreading depolarizations are potentially causing postictal symptoms in epilepsy.
Longitudinal antibody titers measured after COVID-19 mRNA vaccination can identify individuals at risk for subsequent infection | Science Translational Medicine
about 8 hours ago
Individuals at high risk for subsequent SARS-CoV-2 infections can be identified by...
Type I interferon limits central nervous system autoimmunity by modulating the microRNA-21–FOXO1 axis in pathogenic T helper 17 cells | Science Translational Medicine
7 days ago
Type I interferon limits central nervous system autoimmunity by regulating microRNA-21 and...
Interferon-induced senescent CD8+ T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer | Science Translational Medicine
7 days ago
Interferon-induced senescent CD8+ T cells mediate immunotherapy nonresponsiveness in early TNBC, which...
A randomized, double-blind, placebo-controlled phase 1 trial of the topical pan–lysyl oxidase inhibitor PXS-6302 in mature scars | Science Translational Medicine
7 days ago
PXS-6302 reduces hydroxyproline and increases microvasculature in mature scars over baseline and...
Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis | Science Translational Medicine
7 days ago
Restoring TIM4 in liver macrophages in MASH improves the efferocytosis of apoptotic...
Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques | Science Translational Medicine
7 days ago
Humanlike broadly neutralizing B cell lineages to influenza hemagglutinin are elicited in...
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies | Science Translational Medicine
7 days ago
Human myelinated brain organoids with integrated microglia can be used to investigate...