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Last updated 6 days ago
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models | Science Translational Medicine
6 days ago
In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers...
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia | Science Translational Medicine
6 days ago
CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia...
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection | Science Translational Medicine
6 days ago
SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation...
Correcting a pathogenic mitochondrial DNA mutation by base editing in mice | Science Translational Medicine
6 days ago
A mitochondrial DNA editor can make compensatory corrections for a pathological mitochondrial...
Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease | Science Translational Medicine
6 days ago
Tissue microenvironments drive distinct T cell programs in alloimmunity, offering insight into...
AGER-dependent macropinocytosis drives resistance to KRAS-G12D–targeted therapy in advanced pancreatic cancer | Science Translational Medicine
6 days ago
AGER-driven macropinocytosis contributes to resistance against KRAS-G12D–targeted therapy in pancreatic ductal adenocarcinoma.
Perinatal dysfunction of innate immunity in cystic fibrosis | Science Translational Medicine
14 days ago
Evidence from patients and pigs with cystic fibrosis suggests pathological changes in...
Hypoxia as a medicine | Science Translational Medicine
14 days ago
Although hypoxia is often pathologic, chronic continuous hypoxia has shown promise in...
Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation | Science Translational Medicine
14 days ago
Combining transient mixed chimerism with kidney cotransplantation achieves heart allograft tolerance in...
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice | Science Translational Medicine
14 days ago
Targeting integrins relieves on-target, off-tumor toxicity of CAR-T cells while preserving their...
Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease | Science Translational Medicine
14 days ago
Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters...
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy | Science Translational Medicine
20 days ago
Xenon inhalation modulates microglial responses in mice and is a potential therapeutic...