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Last updated 2 days ago
Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors | Science Translational Medicine
2 days ago
Armoring CAR T cells with the ability to secrete VEGF-neutralizing single-chain variable...
Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome | Science Translational Medicine
2 days ago
Switching of MECP2-e2 to the more efficiently translated e1 isoform up-regulates MeCP2...
Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases | Science Translational Medicine
2 days ago
Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and...
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring | Science Translational Medicine
2 days ago
TET-controlled GABA-somatostatin signaling in pancreatic islets underlies intrauterine hyperglycemia-induced glucose intolerance in...
Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice | Science Translational Medicine
2 days ago
Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses...
Drug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat | Science Translational Medicine
2 days ago
The HDAC inhibitor panobinostat is effective against aggressive meningiomas, and resistance is...
Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy | Science Translational Medicine
9 days ago
Actin depolymerization promotes axon regeneration and neuroprotection by enhancing axonal mitochondrial transport.
A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants | Science Translational Medicine
9 days ago
RSV and SARS-CoV-2 infections induce similar interferon but distinct inflammatory, epigenetic, and...
A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance | Science Translational Medicine
9 days ago
A dual-action peptide that activates MST1 can expand and stabilize murine and...
Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation | Science Translational Medicine
9 days ago
Interleukin-1–mediated hyaluronan synthesis in transplanted grafts promotes fibrotic remodeling because of lymphatic...
The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost | Science Translational Medicine
9 days ago
The magnitude and quality of the B cell response to a SARS-CoV-2...
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia | Science Translational Medicine
9 days ago
CRISPR screens identify ZBTB7A as a tumor suppressor gene, and therapeutic targeting...