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Last updated 4 days ago
A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis | Science Translational Medicine
4 days ago
Rapid gene expression changes during treatment of neonatal sepsis indicate reversibility of...
An early clinical trial of 5-ALA sonodynamic therapy in recurrent high-grade glioma | Science Translational Medicine
4 days ago
An early clinical study demonstrates feasibility of noninvasive 5-ALA sonodynamic treatment in...
Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses | Science Translational Medicine
4 days ago
A multipathogen population serological study enabled inference of the antigenic landscape of...
Failure of nerve regeneration in mouse models of diabetes is caused by p35-mediated CDK5 hyperactivity | Science Translational Medicine
4 days ago
Mouse and cell models suggest that GSK3β and the p35-CDK5-CRMP2 axis are...
Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum | Science Translational Medicine
4 days ago
Adjunctive ruxolitinib reduces inflammatory response after experimental malaria challenge and enhances immune...
Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice | Science Translational Medicine
4 days ago
Lymphotoxin alpha represses acute myeloid leukemia by depleting TRAF2 and triggering cell...
Base editing of β0-thalassemia mutations as a therapeutic strategy for severe β-hemoglobinopathies | Science Translational Medicine
4 days ago
Preclinical studies of adenine base editing approaches suggest safety and efficacy for...
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs | Science Translational Medicine
11 days ago
A nonabsorbable, intestinal TGR5-targeted conjugate was designed to improve glycemic control while...
A modular metalloprotein in situ vaccine for cancer immunotherapy in mouse models of breast cancer | Science Translational Medicine
11 days ago
A modular metalloprotein in situ vaccine nanoplatform can establish antitumor immune response.
Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation | Science Translational Medicine
11 days ago
Multiple myeloma cells with chromosome 1q amplification originate from CD24−FCRL5+ B cells...
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models | Science Translational Medicine
11 days ago
Epitope-diverse nanobody cocktails neutralize severe fever with thrombocytopenia syndrome virus and prevent...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice | Science Translational Medicine
11 days ago
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the...