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A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma | Science Translational Medicine
1 day ago
A first-in-class compound targeting the oncogene AVIL demonstrated efficacy and safety in...
Skin thermal dynamics and hypothalamic thermosensitivity dissociate REM sleep and cataplexy in narcolepsy | Science Translational Medicine
1 day ago
Skin temperature modulation and hypothalamic thermosensitivity dissociate REM sleep and cataplexy, independent...
Crystallized colony-stimulating factor-1 receptor inhibitor protects immunoisolated allo but not xeno transplants in primates | Science Translational Medicine
1 day ago
CSF1R-targeted crystals preserve xenogeneic cell function in mice and allogeneic cell function...
Meteorin-like is associated with poor outcome in invasive candidiasis in mouse models and in humans | Science Translational Medicine
1 day ago
METRNL is elevated in candidemia in mice and humans and provides a...
SREBP-1 increases glucose uptake to promote tumor resistance to lysosome inhibition | Science Translational Medicine
1 day ago
Disrupting the SREBP-1–glucose uptake feedforward loop sensitizes tumors to lysosome inhibition–based therapy.
Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis | Science Translational Medicine
9 days ago
CAR T cells generated in vivo by T cell–targeted mRNA-LNP delivery eliminated...
In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis | Science Translational Medicine
9 days ago
The histamine receptor H3 antagonist bavisant promotes neuroprotection and remyelination in cell...
Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity | Science Translational Medicine
9 days ago
Integrated multiome analysis identifies loss of PPARG2 as a driver of liposarcoma...
Erratum for Report “APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia” by G. Sienski et al. | Science Translational Medicine
9 days ago
In the Report “APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia”...
Inhaled nitric oxide at 300 ppm treats multidrug-resistant Pseudomonas pneumonia in swine and is safe in humans | Science Translational Medicine
9 days ago
A swine and human study shows that treating multidrug-resistant Pseudomonas aeruginosa pneumonia...
Quantitative assessment of neonatal health using dried blood spot metabolite profiles and deep learning | Science Translational Medicine
9 days ago
Newborn screen metabolites encapsulate the risk for adverse outcomes of prematurity through...
Dual FAK and EPHA2 targeting by brigatinib tackles PARP inhibitor adaptive survival response in high-grade serous ovarian cancer | Science Translational Medicine
16 days ago
Brigatinib enhances PARPi response in HGSOC by disrupting adaptive survival of malignant...