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Dual FAK and EPHA2 targeting by brigatinib tackles PARP inhibitor adaptive survival response in high-grade serous ovarian cancer | Science Translational Medicine
1 day ago
Brigatinib enhances PARPi response in HGSOC by disrupting adaptive survival of malignant...
Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma | Science Translational Medicine
1 day ago
FACT and BET inhibition in diffuse midline glioma drives tumor suppression and...
Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome | Science Translational Medicine
1 day ago
Soluble CD93 contributes to podocyte injury, and CD93 blockade emerges as a...
An antibody cocktail targeting conserved, nonoverlapping epitopes prevents viral escape and confers protection against RSV in vivo | Science Translational Medicine
1 day ago
An antibody cocktail targeting conserved epitopes on the RSV A and B...
Erratum for the Research Article “Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice” by J. Ramos da Silva et al. | Science Translational Medicine
1 day ago
In the Research Article “Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines...
Brain-derived tau for monitoring brain injury in acute ischemic stroke | Science Translational Medicine
1 day ago
Brain-derived tau in plasma reflects the extent of brain injury in acute...
Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects | Science Translational Medicine
8 days ago
Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and...
Extracellular BRICK1 drives heart repair after myocardial infarction in mice | Science Translational Medicine
8 days ago
The WAVE complex subunit BRICK1 functions as an angiogenic factor driving heart...
Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice | Science Translational Medicine
8 days ago
CNS-targeted hematopoietic stem cell gene therapy shows efficacy in a mouse model...
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine
8 days ago
HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic...
Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions | Science Translational Medicine
8 days ago
Four months instead of the standard 6 months of drug therapy of...
PET/CT imaging of tuberculosis lung lesions in marmosets treated with different drug regimens aligns with human clinical outcomes | Science Translational Medicine
8 days ago
Longitudinal PET/CT imaging data from the lungs of infected marmosets align with...