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Last updated 5 days ago
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis | Science Translational Medicine
5 days ago
LAMP2A functions as a broad-spectrum antifibrotic factor that simultaneously inhibits fibroblast activation...
AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy | Science Translational Medicine
5 days ago
Purified diet feeding and AAV8 therapy are precipitants of cholestatic liver injury...
Baloxavir alleviates severe disease and viremia in ferrets infected with avian- or bovine-origin influenza A(H5N1) virus | Science Translational Medicine
5 days ago
Treating A(H5N1) influenza virus–infected ferrets with baloxavir resulted in greater survival, decreased...
BDNF Val66Met protects oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer | Science Translational Medicine
5 days ago
BDNF Val66Met is a genetic determinant and therapeutic target in CIPN.
Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV | Science Translational Medicine
5 days ago
Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV...
Neutrophil-mediated delivery of antibiotics across the tympanic membrane for otitis media treatment in a preclinical model | Science Translational Medicine
5 days ago
Innate neutrophils were leveraged to deliver antibiotic-containing liposomes across the intact tympanic...
Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer’s disease models | Science Translational Medicine
12 days ago
Levetiracetam prevents Aβ production by reducing synaptic vesicle cycling and restoring APP...
The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity | Science Translational Medicine
12 days ago
Rare human TUB variants impair leptin sensitivity through disruption of STAT3 activation...
Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction | Science Translational Medicine
12 days ago
Renal proximal tubules are sensitive to metabolic acidosis.
Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas | Science Translational Medicine
12 days ago
H3K27M-driven lactylation facilitates nucleotide biosynthesis, an effect that can be exploited for...
Erratum for the Research Article “A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models” | Science Translational Medicine
12 days ago
In the Research Article “A rationally designed cocktail of nanobodies elicited by...
Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma | Science Translational Medicine
12 days ago
Analyses of longitudinal plasma samples from patients with trauma identify biological states...