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Last updated about 17 hours ago

Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors | Science Translational Medicine

about 17 hours ago

Armoring CAR T cells with the ability to secrete VEGF-neutralizing single-chain variable...

Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome | Science Translational Medicine

about 17 hours ago

Switching of MECP2-e2 to the more efficiently translated e1 isoform up-regulates MeCP2...

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases | Science Translational Medicine

about 17 hours ago

Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and...

Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring | Science Translational Medicine

about 17 hours ago

TET-controlled GABA-somatostatin signaling in pancreatic islets underlies intrauterine hyperglycemia-induced glucose intolerance in...

Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice | Science Translational Medicine

about 17 hours ago

Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses...

Drug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat | Science Translational Medicine

about 17 hours ago

The HDAC inhibitor panobinostat is effective against aggressive meningiomas, and resistance is...

Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy | Science Translational Medicine

8 days ago

Actin depolymerization promotes axon regeneration and neuroprotection by enhancing axonal mitochondrial transport.

A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants | Science Translational Medicine

8 days ago

RSV and SARS-CoV-2 infections induce similar interferon but distinct inflammatory, epigenetic, and...

Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation | Science Translational Medicine

8 days ago

Interleukin-1–mediated hyaluronan synthesis in transplanted grafts promotes fibrotic remodeling because of lymphatic...

Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia | Science Translational Medicine

8 days ago

CRISPR screens identify ZBTB7A as a tumor suppressor gene, and therapeutic targeting...