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Science Translational Medicine current issue

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Last updated about 1 month ago

[Research Articles] Neuromodulation using ultra low frequency current waveform reversibly blocks axonal conduction and chronic pain

about 1 month ago

Chronic pain remains a leading cause of disability worldwide, and there is...

[Research Articles] Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis

about 1 month ago

Endometriosis is a common chronic inflammatory condition causing pelvic pain and infertility...

[Research Articles] Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell {alpha}B-crystallin

about 1 month ago

Life-saving renal replacement therapy by peritoneal dialysis (PD) is limited in use...

[Research Articles] Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors

about 1 month ago

Therapeutic approaches are needed to promote T cell–mediated destruction of poorly immunogenic...

[Research Articles] Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy

about 1 month ago

Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly...

[Research Articles] LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade

about 1 month ago

Immune checkpoint blocking antibodies are a cornerstone in cancer treatment; however, they...

[Research Articles] Blocking {alpha}4{beta}7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies

about 1 month ago

Anti-HIV broadly neutralizing antibodies (bNAbs) may favor development of antiviral immunity by...

[Research Articles] Treatment with ROS detoxifying gold quantum clusters alleviates the functional decline in a mouse model of Friedreich ataxia

about 1 month ago

Friedreich ataxia (FRDA) is caused by the reduced expression of the mitochondrial...

[Research Articles] Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

about 1 month ago

Adjuvanted soluble protein vaccines have been used extensively in humans for protection...

[Research Articles] Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

about 1 month ago

ChAdOx1 nCoV-19/AZD1222 is an approved adenovirus-based vaccine for severe acute respiratory syndrome...

[Research Articles] The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia

about 1 month ago

Dystonias are a group of chronic movement–disabling disorders for which highly effective...

[Research Articles] ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156

about 1 month ago

Cancers overcome replicative immortality by activating either telomerase or an alternative lengthening...