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Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects | Science Translational Medicine
1 day ago
Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and...
Extracellular BRICK1 drives heart repair after myocardial infarction in mice | Science Translational Medicine
1 day ago
The WAVE complex subunit BRICK1 functions as an angiogenic factor driving heart...
Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice | Science Translational Medicine
1 day ago
CNS-targeted hematopoietic stem cell gene therapy shows efficacy in a mouse model...
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine
1 day ago
HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic...
Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions | Science Translational Medicine
1 day ago
Four months instead of the standard 6 months of drug therapy of...
PET/CT imaging of tuberculosis lung lesions in marmosets treated with different drug regimens aligns with human clinical outcomes | Science Translational Medicine
1 day ago
Longitudinal PET/CT imaging data from the lungs of infected marmosets align with...
Erratum for Research Article "Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair" by K. Mylonas et al. | Science Translational Medicine
1 day ago
In the Research Article “Cellular senescence inhibits renal regeneration after injury in...
When HIV pays the price: Fitness costs behind lenacapavir resistance | Science Translational Medicine
1 day ago
HIV can take several mutational pathways to become resistant to lenacapavir, each...
Targeting brain hubs of ictal fast ripple activity to reduce seizures in patients with drug-resistant epilepsy | Science Translational Medicine
15 days ago
Epileptic network analysis based on fast ripple interregional coincidence allows us to...
HDAC5 deacetylates cytosolic ACTN4 during skin reepithelialization and represents a therapeutic target for chronic wound healing | Science Translational Medicine
15 days ago
HDAC5 governs wound repair by deacetylating cytosolic ACTN4, and the selective activator...
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection | Science Translational Medicine
15 days ago
Bacteria-targeted tuftsin–presenting nanoparticles stimulate the macrophage Fcγ receptor to improve antimicrobial defenses...
Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation | Science Translational Medicine
15 days ago
A comparison of dermatomyositis and lupus skin revealed that dermatomyositis is characterized...