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Last updated 3 days ago
Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors | Science Translational Medicine
3 days ago
Engineered dendritic cells called iCAR-DCs integrate tumor-antigen uptake with programmable cell activation...
Dual PI3K/mTOR inhibition is required to combat resistance to CDK4/6 inhibitor and endocrine therapy in PIK3CA-mutant breast cancer | Science Translational Medicine
3 days ago
Gedatolisib is more effective than alpelisib in preclinical models of PIK3CA-mutant ER+...
Single–amino acid variants in target epitopes can confer resistance to antibody-based therapies | Science Translational Medicine
3 days ago
Naturally occurring genetic variants in genes encoding human target antigens can confer...
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective | Science Translational Medicine
3 days ago
PIEZO1 restoration protects against tyrosine kinase inhibitor–induced endothelial dysfunction, hypertension, and cardiac...
An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain–related behaviors in humanized mice | Science Translational Medicine
3 days ago
An orally active positive allosteric modulator of the human Mas-related G protein–coupled...
Distinct systemic immune responses in asymptomatic and symptomatic dengue virus infection | Science Translational Medicine
3 days ago
Systemic immune profiling of individuals with asymptomatic or symptomatic dengue reveals distinct...
A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models | Science Translational Medicine
10 days ago
A mineralized collagen scaffold activates Gli1 expression and supports fibrocartilage repair in...
Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy | Science Translational Medicine
10 days ago
Infants from a traditional farming community exhibited antibody profiles that were found...
Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders | Science Translational Medicine
10 days ago
Clinical phenotypes are modestly associated with distinct channel dysfunctions caused by 42...
Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination | Science Translational Medicine
10 days ago
Preclinical models of SARS-CoV-2 vaccination revealed a targetable CXCL10–IFN-γ axis that drives...
Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153 | Science Translational Medicine
10 days ago
Antigen-agnostic isolation of B cells enabled the AI-assisted identification of broadly neutralizing...
A hyperactive splice variant of STAT3 promotes colonic inflammation-associated tumorigenesis in mice | Science Translational Medicine
10 days ago
Alternative splicing resulting in STAT3 that lacks a single amino acid, S701...