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Last updated 2 days ago
Identification and characterization of human retinal stem cells capable of retinal regeneration | Science Translational Medicine
2 days ago
Human neural retinal stem-like cells (hNRSCs) found in fetal retinas and organoids...
Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans | Science Translational Medicine
2 days ago
Comprehensive profiling of Ixodes scapularis antigens reveals that tick bites induce antivector...
Variant screening of PYY3–36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity | Science Translational Medicine
2 days ago
A Y2 receptor–selective and long-acting PYY derivative improves weight loss and glucose...
TRIM15 drives chondrocyte senescence and osteoarthritis progression | Science Translational Medicine
2 days ago
TRIM15 promotes chondrocyte senescence and osteoarthritis progression by mediating K48-linked ubiquitination and...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine
2 days ago
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine...
CAR T cells based on fully human T cell receptor–mimetic antibodies exhibit potent antitumor activity in vivo | Science Translational Medicine
2 days ago
Development of fully human T cell receptor–mimetic antibodies enabled the generation of...
Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy | Science Translational Medicine
9 days ago
Brief administration of tofacitinib enduringly suppresses seizures, restores cognition, and dampens astrogliosis...
T cell receptor precision editing of regulatory T cells for celiac disease | Science Translational Medicine
9 days ago
Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert...
Interneuron-specific dual-AAV SCN1A gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome | Science Translational Medicine
9 days ago
A circuit-selective SCN1A gene replacement AAV approach leverages split inteins to correct...
BASTA, a simple whole-blood assay for measuring β cell antigen–specific CD4+ T cell responses in type 1 diabetes | Science Translational Medicine
9 days ago
β cell antigen–specific CD4+ T cell responses in children with T1D can...
The T cell receptor landscape of childhood brain tumors | Science Translational Medicine
9 days ago
A T cell clonal expansion–activation index is associated with prognosis across types...
Itaconate restrains acute proinflammatory activation of microglia after traumatic brain injury in mice | Science Translational Medicine
16 days ago
The IRG1/itaconate pathway modulates microglial proinflammatory activation after traumatic brain injury in...