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Last updated 3 days ago
In vivo adenine base editing ameliorates Dravet syndrome phenotypes in a mouse model | Science Translational Medicine
3 days ago
Through direct correction of a mutation causing Dravet syndrome, adenine base editing...
Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts | Science Translational Medicine
3 days ago
NKG2A checkpoint inhibition promotes lung fibrosis resolution.
A platform for near real-time and multiplexed monitoring of cerebrospinal fluid biomarkers and flow in neurocritical care | Science Translational Medicine
3 days ago
NeuroSense enables near real-time, multimodal monitoring of external ventricular drains in neurocritical...
Sensory nerves protect against preclinical tendinopathic changes through FGF1 signaling | Science Translational Medicine
3 days ago
Somatosensory neurons prevent tendon degeneration by FGF1-mediated mesenchymal and macrophage regulation.
Prime editing of a pathogenic Scn1a allele ameliorates seizure phenotypes in a GEFS+ mouse model | Science Translational Medicine
3 days ago
Prime editing corrects a pathogenic human SCN1A mutation in mice, reducing seizure...
uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target | Science Translational Medicine
3 days ago
The urokinase receptor uPAR is highly expressed in recurrent glioblastoma and is...
RNA-LNP–mediated in vivo prime editing corrects disease phenotypes in a mouse model of citrullinemia type I | Science Translational Medicine
3 days ago
Prime editing via RNA-LNP corrects multiple pathogenic ASS1 mutations and restores ureagenesis...
VRC01 with antiretroviral initiation in infants is well tolerated, and higher concentrations associate with greater HIV-1 DNA declines | Science Translational Medicine
10 days ago
VRC01 in infants initiating antiretrovirals was well tolerated and associated with lower...
Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis | Science Translational Medicine
10 days ago
Lactate transport inhibitors reprogram fibroblast metabolism to prevent myofibroblast differentiation and reduce...
Extracellular traps from myeloid cells as therapeutic targets in traumatic heterotopic ossification | Science Translational Medicine
10 days ago
Extracellular traps from myeloid cells are present at lesion sites of traumatic...
CD39+CD49a+CD103+ cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice | Science Translational Medicine
10 days ago
CD39+CD49a+CD103+ natural killer cells, elicited by epithelial tumor cell exposure, can control...
Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia | Science Translational Medicine
10 days ago
RBPMS-mediated posttranslational modification plays a crucial role in leukemogenesis by reprogramming FOXO1-mediated...