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Last updated 4 days ago
Targeting brain hubs of ictal fast ripple activity to reduce seizures in patients with drug-resistant epilepsy | Science Translational Medicine
4 days ago
Epileptic network analysis based on fast ripple interregional coincidence allows us to...
HDAC5 deacetylates cytosolic ACTN4 during skin reepithelialization and represents a therapeutic target for chronic wound healing | Science Translational Medicine
4 days ago
HDAC5 governs wound repair by deacetylating cytosolic ACTN4, and the selective activator...
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection | Science Translational Medicine
4 days ago
Bacteria-targeted tuftsin–presenting nanoparticles stimulate the macrophage Fcγ receptor to improve antimicrobial defenses...
Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation | Science Translational Medicine
4 days ago
A comparison of dermatomyositis and lupus skin revealed that dermatomyositis is characterized...
Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts | Science Translational Medicine
4 days ago
ATR/PKMYT1 coinhibition induces synthetic lethality in Rb1-deficient breast cancers, supporting biomarker-guided therapy.
Reconnecting the vagus nerve to the heart through nerve conduit preserves cardiac function in a minipig model of right cardiac vagotomy | Science Translational Medicine
4 days ago
Partial repair of cardiac right vagus nerve using an implantable conduit after...
Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors | Science Translational Medicine
11 days ago
Engineered dendritic cells called iCAR-DCs integrate tumor-antigen uptake with programmable cell activation...
Dual PI3K/mTOR inhibition is required to combat resistance to CDK4/6 inhibitor and endocrine therapy in PIK3CA-mutant breast cancer | Science Translational Medicine
11 days ago
Gedatolisib is more effective than alpelisib in preclinical models of PIK3CA-mutant ER+...
Single–amino acid variants in target epitopes can confer resistance to antibody-based therapies | Science Translational Medicine
11 days ago
Naturally occurring genetic variants in genes encoding human target antigens can confer...
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective | Science Translational Medicine
11 days ago
PIEZO1 restoration protects against tyrosine kinase inhibitor–induced endothelial dysfunction, hypertension, and cardiac...
An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain–related behaviors in humanized mice | Science Translational Medicine
11 days ago
An orally active positive allosteric modulator of the human Mas-related G protein–coupled...
Distinct systemic immune responses in asymptomatic and symptomatic dengue virus infection | Science Translational Medicine
11 days ago
Systemic immune profiling of individuals with asymptomatic or symptomatic dengue reveals distinct...