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Extracellular vesicle–mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice | Science Translational Medicine

2 days ago

High-throughput loading of sgRNA:Cas9 RNPs targeting Myo7aSh1 into extracellular vesicles prevents progressive...

Cationic nanogel–based nasal therapeutic HPV vaccine prevents the development of cervical cancer | Science Translational Medicine

2 days ago

Cationic nanogel–based nasal therapeutic vaccine induces cancer-specific immune responses and inhibits cancer...

Blood-brain barrier opening with neuronavigation-guided focused ultrasound in pediatric patients with diffuse midline glioma | Science Translational Medicine

2 days ago

Neuronavigation-guided focused ultrasound in conjunction with drug delivery can be successfully performed...

Incorporation of 5-methylcytidine alleviates RIG-I–mediated innate immune responses to a self-amplifying RNA vaccine | Science Translational Medicine

2 days ago

Incorporation of 5-methylcytidine alleviates RIG-I–dependent sensing of a self-amplifying RNA vaccine and...

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus | Science Translational Medicine

2 days ago

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic...

EBV and the making of lupus | Science Translational Medicine

2 days ago

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus (Younis et...

snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice | Science Translational Medicine

2 days ago

snoRNA Snord3-mediated epigenetic activation of ESM1 is a potential therapeutic target in...

DLL1-responsive PD-L1+ tumor-associated macrophages promote endocrine resistance in breast cancer | Science Translational Medicine

11 days ago

Triple combination therapy reverses endocrine resistance driven by DLL1high tumor cells, which...

Burst-patterned stimulation restores colonic motility in preclinical models | Science Translational Medicine

11 days ago

Distinct temporal patterns of electrical stimulation of the sacral nerves selectively regulate...

Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens | Science Translational Medicine

11 days ago

MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables...

Depletion of plasmacytoid dendritic cells rescues HIV-reactive stem-like CD8+ T cells during chronic HIV-1 infection | Science Translational Medicine

11 days ago

Plasmacytoid dendritic cells impair HIV-reactive CD8+ T cells in HIV-infected humanized mice...