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Last updated 2 days ago
A phase 1/2a clinical trial to assess safety and immunogenicity of an adenoviral-vectored capsular group B meningococcal vaccine | Science Translational Medicine
2 days ago
The group B meningococcus adenovirus-based vaccine ChAdOx1 MenB.1 is safe and immunogenic...
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry | Science Translational Medicine
2 days ago
Intrathecally dosed antisense oligonucleotide distribution can be imaged in rat and nonhuman...
Patient-derived models of UBA5-associated encephalopathy identify defects in neurodevelopment and highlight potential therapeutic avenues | Science Translational Medicine
2 days ago
Patient-derived cortical organoids facilitate disease modeling and assessment of potential targeted therapies...
Erratum for the Research Article “Treatment of otitis media by transtympanic delivery of antibiotics” by R. Yang et al. | Science Translational Medicine
2 days ago
In the Research Article “Treatment of otitis media by transtympanic delivery of...
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection | Science Translational Medicine
2 days ago
Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection...
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias | Science Translational Medicine
2 days ago
Broad dysregulated splicing in AML partially phenocopies splicing factor mutations, is prognostic...
Mitigating T cell DNA damage during PARP inhibitor treatment enhances antitumor efficacy | Science Translational Medicine
2 days ago
PARP inhibitors damage the DNA of T cells as well as tumor...
A thin cryobiopsy device compatible with transnasal endoscopy for the gastrointestinal tract | Science Translational Medicine
9 days ago
An ultrasmall, image-guided cryobiopsy device supports transnasal biopsy of the gastrointestinal tract...
Hypoglycemia promotes inner blood-retinal barrier breakdown and retinal vascular leakage in diabetic mice | Science Translational Medicine
9 days ago
Hypoglycemia promotes hypoxia-inducible factor-1 (HIF-1)– and HIF-2–dependent retinal vascular hyperpermeability in diabetic...
Objective autonomic signatures of tinnitus and sound sensitivity disorders | Science Translational Medicine
9 days ago
Emotionally evocative sounds elicit pupil dilations and facial movements that index the...
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders | Science Translational Medicine
9 days ago
A tricyclic depletion protocol allows for microglia replacement without preconditioning and mitigates...
Inclusion of a retroviral protease enhances the immunogenicity of VLP-forming mRNA vaccines against HIV-1 or SARS-CoV-2 in mice | Science Translational Medicine
9 days ago
Addition of a retroviral protease to cleave Gag and generate mature virus-like...