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Last updated 5 days ago
Actin depolymerization promotes axon regeneration by restoring axonal mitochondrial transport in mouse models of optic neuropathy | Science Translational Medicine
5 days ago
Actin depolymerization promotes axon regeneration and neuroprotection by enhancing axonal mitochondrial transport.
A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants | Science Translational Medicine
5 days ago
RSV and SARS-CoV-2 infections induce similar interferon but distinct inflammatory, epigenetic, and...
A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance | Science Translational Medicine
5 days ago
A dual-action peptide that activates MST1 can expand and stabilize murine and...
Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation | Science Translational Medicine
5 days ago
Interleukin-1–mediated hyaluronan synthesis in transplanted grafts promotes fibrotic remodeling because of lymphatic...
The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost | Science Translational Medicine
5 days ago
The magnitude and quality of the B cell response to a SARS-CoV-2...
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia | Science Translational Medicine
5 days ago
CRISPR screens identify ZBTB7A as a tumor suppressor gene, and therapeutic targeting...
Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis | Science Translational Medicine
12 days ago
LAMP2A functions as a broad-spectrum antifibrotic factor that simultaneously inhibits fibroblast activation...
AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy | Science Translational Medicine
12 days ago
Purified diet feeding and AAV8 therapy are precipitants of cholestatic liver injury...
Baloxavir alleviates severe disease and viremia in ferrets infected with avian- or bovine-origin influenza A(H5N1) virus | Science Translational Medicine
12 days ago
Treating A(H5N1) influenza virus–infected ferrets with baloxavir resulted in greater survival, decreased...
BDNF Val66Met protects oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer | Science Translational Medicine
12 days ago
BDNF Val66Met is a genetic determinant and therapeutic target in CIPN.
Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV | Science Translational Medicine
12 days ago
Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV...
Neutrophil-mediated delivery of antibiotics across the tympanic membrane for otitis media treatment in a preclinical model | Science Translational Medicine
12 days ago
Innate neutrophils were leveraged to deliver antibiotic-containing liposomes across the intact tympanic...