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Last updated 4 days ago

Genomic instability drives POSTN+ myofibroblasts via STING-WNT axis to promote immunosuppression and PARPi resistance in ovarian cancer | Science Translational Medicine

4 days ago

Epigenetic reprogramming of POSTN+ myCAFs converts genome instability–induced immune activation into suppression...

Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma | Science Translational Medicine

4 days ago

Durcabtagene autoleucel, a rapidly manufactured BCMA-directed CAR T cell therapy, was safe...

The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain | Science Translational Medicine

4 days ago

[11C]MODAG-005 showed high-affinity binding to α-synuclein aggregates and was validated in brain...

Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models | Science Translational Medicine

10 days ago

Reprogrammed apoptotic platelets stop complex bleeding through surface phosphatidylserine and PTGES/PGE2 signaling.

Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension | Science Translational Medicine

11 days ago

A BMP target engagement biomarker panel, developed through the StratosPHere 1 study...

Transcranial ultrasound stimulation of motor networks in Parkinson’s disease informed by local field potential dynamics | Science Translational Medicine

11 days ago

TUS can alter subthalamic activity in a target-specific, frequency band–specific, and brain...

Urinary fluorogenic reporters for noninvasive detection and staging of kidney fibrosis | Science Translational Medicine

11 days ago

Fibrogenesis sensing reporters provide a noninvasive approach for identification of kidney fibrosis...