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Last updated 4 days ago
A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models | Science Translational Medicine
4 days ago
A mineralized collagen scaffold activates Gli1 expression and supports fibrocartilage repair in...
Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy | Science Translational Medicine
4 days ago
Infants from a traditional farming community exhibited antibody profiles that were found...
Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders | Science Translational Medicine
4 days ago
Clinical phenotypes are modestly associated with distinct channel dysfunctions caused by 42...
Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination | Science Translational Medicine
4 days ago
Preclinical models of SARS-CoV-2 vaccination revealed a targetable CXCL10–IFN-γ axis that drives...
Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153 | Science Translational Medicine
4 days ago
Antigen-agnostic isolation of B cells enabled the AI-assisted identification of broadly neutralizing...
A hyperactive splice variant of STAT3 promotes colonic inflammation-associated tumorigenesis in mice | Science Translational Medicine
4 days ago
Alternative splicing resulting in STAT3 that lacks a single amino acid, S701...
ZAP327 signaling domain–driven chimeric antigen receptor generates robust and long-term antitumor immunity in mouse models | Science Translational Medicine
4 days ago
ZAP327 CAR T cells outperform conventional CAR T cells in antitumor efficacy...
Erratum for the Research Article “Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis” by Z. Zhang et al. | Science Translational Medicine
4 days ago
In the Research Article “Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease...
Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling | Science Translational Medicine
11 days ago
Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages...
Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury | Science Translational Medicine
11 days ago
Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.
A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice | Science Translational Medicine
11 days ago
A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies...
Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD | Science Translational Medicine
11 days ago
Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune...