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Treatment of Shiga toxin–producing E. coli infection by CRISPR-Cas–targeted cleavage of the Shiga toxin gene in animal models | Science Translational Medicine
1 day ago
A phage-derived particle killed more than 90% of STEC O157 strains via...
Genomic instability drives POSTN+ myofibroblasts via STING-WNT axis to promote immunosuppression and PARPi resistance in ovarian cancer | Science Translational Medicine
1 day ago
Epigenetic reprogramming of POSTN+ myCAFs converts genome instability–induced immune activation into suppression...
Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma | Science Translational Medicine
1 day ago
Durcabtagene autoleucel, a rapidly manufactured BCMA-directed CAR T cell therapy, was safe...
Coordinated regulation using small-molecule drugs enables controlled therapeutic genome editing and enhanced genomic precision in situ | Science Translational Medicine
1 day ago
Coordinated delivery of small-molecule drugs allows precise control over therapeutic genome editing...
The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain | Science Translational Medicine
1 day ago
[11C]MODAG-005 showed high-affinity binding to α-synuclein aggregates and was validated in brain...
CCR5 and CD74 are potential therapeutic targets for necroinflammation in preclinical cholesterol crystal embolism | Science Translational Medicine
1 day ago
Inhibition of CCR5 and CD74 offers a new strategy to curb necroinflammation...
Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models | Science Translational Medicine
7 days ago
Reprogrammed apoptotic platelets stop complex bleeding through surface phosphatidylserine and PTGES/PGE2 signaling.
Real-time in vivo analysis of murine β cells reveals autophagic flux defects before onset of autoimmune diabetes | Science Translational Medicine
8 days ago
Dynamic in vivo 4D analysis of β cell autophagic flux in mice...
A mitochondrial ROS–dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes | Science Translational Medicine
8 days ago
IFN-α stimulates mitochondrial ROS production in a subset of healthy human β...
Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension | Science Translational Medicine
8 days ago
A BMP target engagement biomarker panel, developed through the StratosPHere 1 study...
Transcranial ultrasound stimulation of motor networks in Parkinson’s disease informed by local field potential dynamics | Science Translational Medicine
8 days ago
TUS can alter subthalamic activity in a target-specific, frequency band–specific, and brain...
Urinary fluorogenic reporters for noninvasive detection and staging of kidney fibrosis | Science Translational Medicine
8 days ago
Fibrogenesis sensing reporters provide a noninvasive approach for identification of kidney fibrosis...