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Last updated 5 days ago
Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models | Science Translational Medicine
5 days ago
YL-5092, a selective first-in-class YTHDC1 inhibitor, impairs AML progression in preclinical studies...
The E205D mutation in CYP6P3 drives pyrethroid insecticide resistance in the African malaria mosquito vector Anopheles gambiae | Science Translational Medicine
5 days ago
The E205D point mutation in the key detoxification gene CYP6P3 increases insecticide...
Kras G12C– and G12D–driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models | Science Translational Medicine
5 days ago
KRAS G12D and G12C produce lung tumors with distinct microenvironmental and growth...
Phase 1 and preclinical studies reveal safety, pharmacokinetics, and efficacy of intranasal delivery of the influenza antibody CR9114 | Science Translational Medicine
5 days ago
Intranasal CR9114 is safe in humans, and twice-daily dosing confers protection against...
Sine oculis homeobox 1 drives endothelial dysfunction in preclinical pulmonary arterial hypertension | Science Translational Medicine
5 days ago
Targeting sine oculis homeobox 1 alleviates pulmonary arterial hypertension.
Erratum for the Research Article “Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia” | Science Translational Medicine
5 days ago
Two panels of Fig. 2 in the Research Article “Calmodulin inhibitors improve...
Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells | Science Translational Medicine
5 days ago
CAR T cells against the IGHV4-34 B cell receptor specifically target pathogenic...
A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma | Science Translational Medicine
12 days ago
A first-in-class compound targeting the oncogene AVIL demonstrated efficacy and safety in...
Skin thermal dynamics and hypothalamic thermosensitivity dissociate REM sleep and cataplexy in narcolepsy | Science Translational Medicine
12 days ago
Skin temperature modulation and hypothalamic thermosensitivity dissociate REM sleep and cataplexy, independent...
Crystallized colony-stimulating factor-1 receptor inhibitor protects immunoisolated allo but not xeno transplants in primates | Science Translational Medicine
12 days ago
CSF1R-targeted crystals preserve xenogeneic cell function in mice and allogeneic cell function...
Meteorin-like is associated with poor outcome in invasive candidiasis in mouse models and in humans | Science Translational Medicine
12 days ago
METRNL is elevated in candidemia in mice and humans and provides a...
SREBP-1 increases glucose uptake to promote tumor resistance to lysosome inhibition | Science Translational Medicine
12 days ago
Disrupting the SREBP-1–glucose uptake feedforward loop sensitizes tumors to lysosome inhibition–based therapy.