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Last updated 5 days ago

Anti-inflammatory, but not lipid-lowering, activity of hepatocyte PPARα improves atherosclerosis in Ldlr-deficient mice | Science Translational Medicine

5 days ago

Hepatic inflammation-targeting pemafibrate reduces atherosclerosis in Ldlr−/− mice, supporting a role for...

MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis | Science Translational Medicine

5 days ago

The immunosuppressive capacity of regulatory T cell–derived extracellular vesicles is reduced in...

Peripherally induced RORγt+ skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy | Science Translational Medicine

5 days ago

RORγt+FoxP3+ skin-resident regulatory T cells from the periphery contribute to the therapeutic...

Systemic delivery of cadherin 17–specific CAR T cells allows effective and safe targeting of colorectal cancer liver metastases | Science Translational Medicine

5 days ago

Systemic cadherin-17–specific CAR T cell therapy is efficacious against colorectal cancer liver...

Islet transplantation in immunomodulatory nanoparticle–remodeled spleens | Science Translational Medicine

12 days ago

Islet transplants growing in tissue-remodeled spleens restore normoglycemia in diabetic mice and...

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer | Science Translational Medicine

12 days ago

Tumors with chromosomal instability accrue DNA sequence mutations at highly variable rates...

Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1–induced platelet reactivity | Science Translational Medicine

12 days ago

Dose-dependent platelet inhibition by icosapent ethyl contributes to beneficial effects of polyunsaturated...

Human monoclonal antibodies targeting subdominant meningococcal antigens confer cross-protection against gonococcus | Science Translational Medicine

12 days ago

Human monoclonal antibodies isolated from meningococcus B vaccinees enabled identification of gonococcal...