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Last updated 7 days ago
Dipeptidyl aminopeptidase–like protein 6 regulates the INa-Ito balance influencing cardiac electrophysiology and arrhythmogenesis | Science Translational Medicine
7 days ago
DPP6 regulates the cardiac INa-Ito balance, which is aberrantly influenced by clinically...
Adeno-associated virus gene therapy–mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques | Science Translational Medicine
7 days ago
A single dose of an AAV vector encoding the CCR5-blocking antibody leronlimab...
The internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells in vivo | Science Translational Medicine
7 days ago
Disrupting the ILM in vivo permits retinal integration of transplanted RGCs, enabling...
Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease | Science Translational Medicine
7 days ago
Genomic regulation of protein abundance differs substantially between human biofluids, affecting neurological...
Local B cell immunity and durable memory after live-attenuated influenza intranasal vaccination of humans | Science Translational Medicine
7 days ago
Longitudinal nasopharyngeal sampling reveals local influenza-specific B cell responses after intranasal, but...
Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4+ T cell responses | Science Translational Medicine
7 days ago
Samples from patients with chronic hepatitis B and a mouse model revealed...
Erratum for the Research Article “Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma” | Science Translational Medicine
7 days ago
In the experiment depicted in Fig. 5C of the Research Article “Inhibiting...
Erratum for the Research Article “Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling” | Science Translational Medicine
7 days ago
After publication of the Research Article “Targeted disruption of the BCL9/β-catenin complex...
Phase separation–based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression | Science Translational Medicine
14 days ago
The FDA-approved MEK1/2 inhibitor cobimetinib targets the YAP-TEAD complex to suppress hyperactivated...
Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2-related neurodevelopmental disorder | Science Translational Medicine
14 days ago
ASO-mediated Hnrnph2 knockdown up-regulates Hnrnph1 and rescues multiple phenotypes in a mouse...
Functional correction of the untreatable CFTR 1717-1G>A mutation through mRNA- and sgRNA-optimized base editing | Science Translational Medicine
14 days ago
An RNA-delivered base editing strategy efficiently corrects the CFTR 1717-1G>A mutation that...
Diabetes-induced TREM2–endothelial cell signaling impairs ischemic vascular repair | Science Translational Medicine
14 days ago
Diabetes-driven TREM2-endothelial cross-talk impairs vascular repair in peripheral arterial disease.