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Last updated 6 days ago
Now with oligos: antibody–oligonucleotide conjugates are the new drug modality to watch
6 days ago
Nature Biotechnology, Published online: 06 January 2026; doi:10.1038/s41587-025-02987-0Developers have married gene-modulating oligonucleotides...
Balancing immunity with Tregs
6 days ago
Nature Biotechnology, Published online: 06 January 2026; doi:10.1038/s41587-025-02990-5Insights into regulatory T cell...
CRISPR–Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02949-6Cas3 nuclease is used for...
Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02890-8Engineered inhalable exosomes deliver a...
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02965-6Differential isoform usage is identified...
Machine learning framework reveals a concordant cell-state landscape across single-cell datasets
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02978-1Comprehensively resolving the cell state...
Moving beyond monogenic disorders in clinical healthcare
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02931-2Our understanding of the genetic...
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02950-zCONCORD generates denoised cell encodings...
Integrated experimental and AI innovations for RNA structure determination
6 days ago
Nature Biotechnology, Published online: 05 January 2026; doi:10.1038/s41587-025-02974-5RNA’s dynamic nature and complex...
Troubleshooting common errors in assemblies of long-read metagenomes
10 days ago
Nature Biotechnology, Published online: 02 January 2026; doi:10.1038/s41587-025-02971-8Long-read sequence assemblies from metagenomes...
Single-strand deaminase-assisted editing for functional RNA manipulation
10 days ago
Nature Biotechnology, Published online: 02 January 2026; doi:10.1038/s41587-025-02956-7A single-strand deaminase-assisted platform simultaneously...
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles
10 days ago
Nature Biotechnology, Published online: 02 January 2026; doi:10.1038/s41587-025-02930-3Codelivery of an antifungal drug...