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Last updated 12 days ago
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR | Science
12 days ago
Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of...
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science
12 days ago
Flexibility and stability of neuronal ensembles are crucial features of brain function...
Duck-billed dinosaur fleshy midline and hooves reveal terrestrial clay-template “mummification” | Science
19 days ago
Two “mummies” of the end-Cretaceous, duck-billed dinosaur Edmontosaurus annectens preserve a fleshy...
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes | Science
19 days ago
Phenotypic drug screening remains constrained by the vastness of chemical space and...
Liquid-state dipolarcaloric refrigeration cycle with nitrate-based salts | Science
19 days ago
Environmental burden of vapor compression refrigeration has driven interest in alternatives. Caloric...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase | Science
26 days ago
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating...
Biocatalytic, asymmetric radical hydrogenation of unactivated alkenes | Science
26 days ago
Alkene hydrogenation is a cornerstone of chemical synthesis, yet enzymatic strategies remain...
Higher education fails at collective action | Science
26 days ago
In the latest development in the ongoing combat between universities in the...
Constraints on lepton number violation with the 2 tonne · year CUORE Dataset | Science
26 days ago
Matter-antimatter asymmetry underlines the incompleteness of the current understanding of particle physics...
Flexible nanoelectronics reveal arrhythmogenesis in transplanted human cardiomyocytes | Science
26 days ago
The transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offers a...
Scientific distinctions between coca and cocaine support policy reform | Science
27 days ago
Ongoing review of international drug policy should correct long-standing, misguided, and harmful...
Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2 | Science
about 1 month ago
Genetic disruption of the RAS binding domain (RBD) of Phosphoinositide 3-kinase alpha(PI3Kα)...