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Last updated 3 days ago
Severe obesity in human HFpEF alters contractile protein function and organization | Science
4 days ago
Heart failure with preserved ejection fraction (HFpEF) causes substantial morbidity and mortality...
Microtubule dynamics control the direction of cardiomyocyte growth | Science
4 days ago
The adult heart grows by addition of sarcomeres along the length or...
Stopping phase reveals abrupt arrest of large strike-slip earthquakes | Science
4 days ago
Earthquake magnitude is controlled by where and when rupture propagation stops. Yet...
Structural N- and O-glycans revealed by high-resolution cryo-EM analysis of tubular mastigonemes | Science
4 days ago
The chemical complexity and non-templated biosynthesis of glycans have posed significant challenges...
Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase | Science
11 days ago
Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional...
Device-scaling constraints imposed by the van der Waals gap formed in two-dimensional materials | Science
11 days ago
Transistor miniaturization requires controlling gate leakage through ultrathin dielectrics and minimizing source/drain...
Reimagining human-centric drug development with new approach methodologies | Science
11 days ago
Despite unprecedented technological progress, most drug candidates continue to fail in clinical...
Divergent and programmable skeletal remodeling of complex macrocycles with a small method set | Science
25 days ago
The bioactivity of complex organic macrocycles can vary unpredictably with their three-dimensional...
Editorial Expression of Concern for the Research Article “Kinetic organization of the genome revealed by ultraresolution multiscale live imaging” by J. Lee et al. | Science
25 days ago
On 18 September 2025, Science published the Research Article "Kinetic organization of...
A high-throughput selection system for fast-acting covalent protein drugs | Science
25 days ago
Covalent protein drugs offer therapeutic potential but are limited by slow target...
High-temperature memristors enabled by interfacial engineering | Science
about 1 month ago
Non-volatile memories (NVM) that operate reliably at high temperature are essential for...
Unstructured transcription factor interactions enable emergent specificity | Science
about 1 month ago
How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of...