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Last updated 4 days ago
Recurrent acquisition of nuclease-protease pairs in antiviral immunity | Science
5 days ago
Antiviral immune systems diversify by integrating new genes into existing pathways, creating...
Three-component assembly and structure–function relationships of (–)-gukulenin A | Science
5 days ago
α-Tropolones comprise an unsaturated seven-membered ring bearing a hydroxyl substituent adjacent to...
A whole-brain single-cell atlas of circadian neural activity in mice | Science
5 days ago
The mammalian brain comprises numerous anatomical regions with distinct functions despite their...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science
5 days ago
Non-LTR retrotransposon proteins copy their RNA template into a genome via coordinated...
Termination of the integrated stress response | Science
5 days ago
Stress responses enable cells to detect, adapt to, and survive challenges. The...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science
12 days ago
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine...
Experimental evidence for nodal superconducting gap in moiré graphene | Science
12 days ago
Understanding the nature of superconductivity in magic-angle graphene remains challenging. A key...
Postdomestication selection of MKK3 shaped seed dormancy and end-use traits in barley | Science
12 days ago
Anthropogenic selection of grain traits such as dormancy has shaped the developmental...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis | Science
12 days ago
Folate metabolism is intricately linked to purine de novo synthesis through the...
The origin of hepatocellular carcinoma depends on metabolic zonation | Science
12 days ago
The origin of cancer is poorly understood because premalignant cells are rarely...
Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2 | Science
12 days ago
Homologous recombination repairs DNA double strand breaks and protects stalled replication forks...
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR | Science
19 days ago
Variants in the familial hypercholesterolemia gene LDLR—the most important genetic driver of...