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Last updated 12 days ago

Divergent and programmable skeletal remodeling of complex macrocycles with a small method set | Science

12 days ago

The bioactivity of complex organic macrocycles can vary unpredictably with their three-dimensional...

A high-throughput selection system for fast-acting covalent protein drugs | Science

12 days ago

Covalent protein drugs offer therapeutic potential but are limited by slow target...

High-temperature memristors enabled by interfacial engineering | Science

19 days ago

Non-volatile memories (NVM) that operate reliably at high temperature are essential for...

Unstructured transcription factor interactions enable emergent specificity | Science

26 days ago

How intrinsically disordered regions (IDRs) influence chromatin binding and nuclear organization of...

Agroseismology and the impact of farming practices on soil hydrodynamics | Science

26 days ago

Impacts of farming practices on soil hydrodynamics are central to understanding agricultural...

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | Science

26 days ago

Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic...

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis | Science

about 1 month ago

The hypothalamic-pituitary-gonadal axis (HPG) controls pubertal development, sexual maturation, and fertility. We...

A deep-time landscape of plant cis-regulatory sequence evolution | Science

about 1 month ago

Developmental gene function is often conserved over deep time, but cis-regulatory sequence...

A molecule with half-Möbius topology | Science

about 1 month ago

Stereoisomers of C13Cl2 exhibiting helical orbitals around a ring of carbon atoms...

A unified platform for nucleoside analog synthesis | Science

about 1 month ago

Nucleoside analogs (NAs) are essential as antiviral and anticancer therapies. Despite decades...

Ferroelectricity in atomic-scale titanium dioxide dielectric films | Science

about 1 month ago

Ferroelectricity at atomic-scale thickness would have important applications in next-generation electronics. Here...