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Last updated 1 day ago

TranscriptFormer: A generative cell atlas across 1.5 billion years of evolution | Science

2 days ago

Single-cell transcriptomics is revolutionizing our understanding of cellular diversity, yet comparing transcriptional...

Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design | Science

2 days ago

A major obstacle confronting HIV-1 vaccine and cure research is the lack...

A 481-meter-high landslide-tsunami in a cruise ship–frequented Alaska fjord | Science

3 days ago

Early in the morning of 10 August 2025, a >64 × 106...

Severe obesity in human HFpEF alters contractile protein function and organization | Science

16 days ago

Heart failure with preserved ejection fraction (HFpEF) causes substantial morbidity and mortality...

Microtubule dynamics control the direction of cardiomyocyte growth | Science

16 days ago

The adult heart grows by addition of sarcomeres along the length or...

Stopping phase reveals abrupt arrest of large strike-slip earthquakes | Science

16 days ago

Earthquake magnitude is controlled by where and when rupture propagation stops. Yet...

Structural N- and O-glycans revealed by high-resolution cryo-EM analysis of tubular mastigonemes | Science

16 days ago

The chemical complexity and non-templated biosynthesis of glycans have posed significant challenges...

Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase | Science

23 days ago

Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional...

Device-scaling constraints imposed by the van der Waals gap formed in two-dimensional materials | Science

23 days ago

Transistor miniaturization requires controlling gate leakage through ultrathin dielectrics and minimizing source/drain...

Reimagining human-centric drug development with new approach methodologies | Science

23 days ago

Despite unprecedented technological progress, most drug candidates continue to fail in clinical...

A high-throughput selection system for fast-acting covalent protein drugs | Science

about 1 month ago

Covalent protein drugs offer therapeutic potential but are limited by slow target...