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Last updated 1 day ago
Development of clinically viable non-muscle myosin II small molecule inhibitors
1 day ago
Development of selective small molecule inhibitors that specifically avoid cardiac muscle myosin...
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation
1 day ago
A synonymous mutation in aminocyclopropane-1-carboxylic acid synthase controls cucumber fruit length domestication...
Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids
3 days ago
Recapitulating the concurrent development of germ layers through the co-differentiation of mesoderm...
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity
3 days ago
T cell receptor proximity plays a critical role in MHC class II-dependent...
Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications
3 days ago
Analysis of the conserved intercellular interactome in human vascular dementia and in...
Functional assessment of all ATM SNVs using prime editing and deep learning
6 days ago
Prime editing combined with machine learning-based evaluation of all 27,513 possible coding...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
6 days ago
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense...
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation
7 days ago
This work introduces Flysta3D-v2, a 3D spatiotemporal multi-omics database that spans Drosophila...
Systematic profiling reveals betaine as an exercise mimetic for geroprotection
8 days ago
Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine...
Response to: The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved
8 days ago
Optimized density supports the building of GMPPNP, and an improved mechanism for...
A host organelle integrates stolen chloroplasts for animal photosynthesis
8 days ago
Sea slugs steal foreign chloroplasts and store them in specialized organelles that...
The mechanism for GTP-mediated RNA capping by the SARS-CoV-2 NiRAN domain remains unresolved
8 days ago
This Matters Arising paper questions a prior study describing a mechanism of...