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Last updated 3 days ago
SARM1 senses dsDNA to promote NAD+ degradation and cell death
3 days ago
Detection of DNA is a fundamental strategy for life to recognize non-self...
Adrenergic signaling coordinates distant and local responses to amputation in axolotl
3 days ago
The nervous system regulates a systemic response following amputation that primes distant...
Protein restriction reprograms the multi-organ proteomic landscape of mouse aging
3 days ago
Comprehensive proteomic analysis of 41 mouse tissues reveals tissue-specific aging hallmarks and...
Unveiling conformation-selective regulation of the norepinephrine transporter
3 days ago
The inward-open-state-specific allosteric site in NET was structurally characterized, enabling the rational...
Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance
3 days ago
Cancer cells exploit distant tissues and organs to escape immune surveillance by...
Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2
5 days ago
Structures of the SARS-CoV-2 replication-transcription complex in the pre- and post-capping initiation...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
5 days ago
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying it to...
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success
10 days ago
CD8+ T cells preferentially engage tumor cells in pockets termed CRATERs, which...
Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson???s disease
11 days ago
High-purity dopaminergic progenitors were generated from human embryonic stem cells, and their...
De novo designed voltage-gated anion channels suppress neuron firing
11 days ago
This study reports the successful de novo design of voltage-gated anion channels...
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
12 days ago
The first-in-human study of anti-BCMA CAR-T therapy for progressive multiple sclerosis shows...
The genomic footprints of wild Saccharum species trace domestication, diversification, and modern breeding of sugarcane
13 days ago
Genomic analyses of 390 accessions reveal the domestication history of highly polyploid...