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Last updated 2 days ago
Hallmarks of cancer—Then and now, and beyond
2 days ago
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of...
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin
2 days ago
Sympathetic nerves regulate skin immunity by engaging keratinocytes to modulate the density...
Molecular features of human pathological tau distinguish tauopathy-associated dementias
2 days ago
The FLEXITau platform provides detailed, quantitative, peptide-resolved molecular maps of tau for...
Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics
2 days ago
Stimulating ventral basal ganglionic targets modulates a dynamic amOFC biomarker linked to...
A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis
3 days ago
The RFC clamp loader remains associated with PCNA beyond the loading step...
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
3 days ago
Structural and functional analyses elucidate the mechanisms by which two ATP-independent RNA...
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
3 days ago
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4...
A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor
3 days ago
Engineered repressible promoters enable tunable fluorescence outputs in Bacteroides and the development...
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator
4 days ago
Identification of atazanavir as a pan-positive allosteric modulator for family A GPCRs...
An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery
4 days ago
Organ-level localized delivery is a long-standing challenge, especially for gene therapy. This...
An uORF-encoded mobile peptide sparks systemic stomatal immunity
4 days ago
In Arabidopsis, the uORF-encoded long-distance mobile peptide USIC in pathogen-infected local leaves...
A triple-node heart-brain neuroimmune loop underlying myocardial infarction
4 days ago
This study explores the dissection of a neuroimmune pathway involving the sensory...