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Cell Stem Cell
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Last updated 6 days ago
A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
6 days ago
(Cell Stem Cell 22, 893–908.e1–e6; June 1, 2018)
TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation
6 days ago
Liu and colleagues developed TIGRa, an ultra-compact programmable gene activator that efficiently...
Morphogen-guided neocortical organoids with anteroposterior areal identity
6 days ago
Tsai et al. describe a transient morphogen exposure strategy that establishes anterior...
Human heart valve-like tissues from pluripotent stem cells with enhanced maturation recapitulate inflammatory valve disease
6 days ago
Voges and colleagues develop 3D bioengineered heart valve tissue from human pluripotent...
Human iPSC-derived heart valve-like assembloids model valve development and disease pathology
6 days ago
Human heart valve biology has been difficult to study in faithful in...
Splenic extramedullary hematopoiesis in myelofibrosis is shaped by transcriptomic and epigenetic dysregulation
6 days ago
Hoffman, Aifantis, Satija, and colleagues show that neoplastic extramedullary hematopoiesis in the...
Spatial profiling of the spleen in mouse and human myelofibrosis reveals complement-driven immune-stromal interactions as a therapeutic target
6 days ago
Schneider, Dussiau, and colleagues show that splenomegaly in myelofibrosis reflects active remodeling...
Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains
6 days ago
Blanchard and colleagues developed a multicellular integrated brain (miBrain) recapitulating α-synuclein pathogenic...
Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types
6 days ago
Many cancers lack suitable molecular targets for radiotheranostics. Liu and colleagues engineer...
Ovarian aging and systemic health: Mechanisms and emerging intervention strategies
6 days ago
Ovarian aging may accelerate systemic aging beyond fertility decline. Jing et al...
Feeling the tension: Engineered stem cells convert tumor stiffness into a drug target
6 days ago
Radiopharmaceutical theranostics remains constrained by tumors lacking a validated molecular target. Yang...
Beyond compensation: Organized pathological hematopoiesis in the myelofibrotic spleen
6 days ago
Two studies in this issue of Cell Stem Cell show that splenic...