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Last updated 8 days ago
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories
8 days ago
We developed a plain text modeling language—a cell behavior hypothesis grammar—to easily...
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue
8 days ago
Pairing imaging and sequencing to simultaneously measure gene expression and morphological phenotypes...
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation
8 days ago
This work introduces Flysta3D-v2, a 3D spatiotemporal multi-omics database that spans Drosophila...
Digital reconstruction of full embryos during early mouse organogenesis
8 days ago
Single-cell digital embryo reconstruction during early organogenesis creates spatiotemporal atlases for mesoderm...
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy
8 days ago
Enforced mitophagy enables efficient mitochondrial depletion in pluripotent stem cells and embryos...
Advancing protein evolution with inverse folding models integrating structural and evolutionary constraints
8 days ago
An AI-informed approach integrates generic protein inverse folding models with structural and...
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
8 days ago
Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells...
Inner speech in motor cortex and implications for speech neuroprostheses
8 days ago
Inner speech is robustly represented in the motor cortex and can be...
MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
8 days ago
MT-125 is a small-molecule inhibitor of non-muscle myosin IIA and IIB that...
Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales
8 days ago
High-throughput recombination site screening with AI-assisted recombinase engineering allows for the development...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
8 days ago
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This...
Development of clinically viable non-muscle myosin II small molecule inhibitors
8 days ago
Development of selective small molecule inhibitors that specifically avoid cardiac muscle myosin...