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Last updated 3 days ago
A single-cell time-series atlas of endothelial cell embryonic development
3 days ago
The STED-EC atlas enables inter-organ and multi-time-point comparisons of gene expression in...
CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response
3 days ago
CLIM-TIME provides a high-throughput perturbation-mapping platform that links tumor suppressor gene loss...
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
3 days ago
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4...
Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury
3 days ago
Generation of brain-wide oligodendrocyte atlases across aging, disease, sex, and strain reveals...
Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target
3 days ago
Or5v1/Olfr110, a high-affinity odor receptor, detects an oxylipin signal to boost liver...
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
3 days ago
Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments...
Structural decoding of reversible covalent linkage of odorants in human olfactory receptor OR6A2
3 days ago
The human olfactory receptor OR6A2, re-engineered to be functional, demonstrates the mechanism...
Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors
3 days ago
Cryo-EM structures reveal how Olfr110, a class II odorant receptor, binds hydrophobic...
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
3 days ago
Giant DNA viruses encode a cap-binding complex homologous to eIF4F, the defining...
A regulatory network promotes apoplastic alkalinization to prime plant immunity in tissues distal to site of infection
3 days ago
Pathogen-exposed plant cells communicate with neighboring cells through apoplastic alkalinization and phytocytokines...
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator
3 days ago
Identification of atazanavir as a pan-positive allosteric modulator for family A GPCRs...
An uORF-encoded mobile peptide sparks systemic stomatal immunity
3 days ago
In Arabidopsis, the uORF-encoded long-distance mobile peptide USIC in pathogen-infected local leaves...