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Last updated 5 days ago
Bacteriophage genome-wide transposon mutagenesis
5 days ago
A technique enabling phage transposon mutagenesis and sequencing reveals previously unknown non-essential...
Multimodal imaging of gene expression, morphology, and activity of the same neuron
5 days ago
This study establishes an imaging-based multimodal characterization (IMC) platform to link in...
Map of spiking activity underlying change detection in the mouse visual system
5 days ago
Large-scale Neuropixels recordings across the mouse visual system during an image-change detection...
Decoding the spatiotemporal development of human meninges
5 days ago
A spatiotemporal atlas of the human meninges during early-to-mid gestation identifies asynchronous...
Physiological brain clearance architecture revealed by neuronal protein tracing
5 days ago
Neuronal protein tracing, unlike CSF tracers, reveals that brain clearance follows a...
TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy
5 days ago
Characterization of TPPP/p25 amyloid aggregation enables the development of a seed amplification...
Arc mediates intercellular tau transmission via extracellular vesicles
5 days ago
Tau pathology spreads cell to cell in Alzheimer’s disease, but the molecular...
Two distinct causes contribute to the low efficiency of human pre-implantation development
5 days ago
Live imaging covering the entire human pre-implantation development reveals that the second...
Continuous modeling of primate embryogenesis from totipotency to early organogenesis
5 days ago
A primate embryoid system is established from cynomolgus totipotent blastomere-like cells. This...
Harnessing citizen science to contextualize adaptation mechanism discovery
5 days ago
Juxtaposing citizen science in situ observations and designed ex situ experiments through...
A spliceosome-independent eukaryote generated by complete intron removal
5 days ago
Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
5 days ago
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered...