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Last updated 9 days ago
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
9 days ago
BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested non-coding regulatory...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation
9 days ago
Myelin-reactive B cells entering the central nervous system capture cognate antigen from...
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment
9 days ago
Clinical evidence from AD patients reveals an association between impaired CCKBR-Gq signaling...
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
9 days ago
Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent...
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi
9 days ago
Chen et al. identify the natural product butyrolactol A as an inhibitor...
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense
9 days ago
Dendritic cells in lymph nodes orchestrate large-scale innate effector cell trafficking to...
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
9 days ago
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis...
EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation
9 days ago
EBV infection alters the transcriptome of B cells, which leads to presentation...
Establishing the relationship between brain cellular senescence and brain structure
9 days ago
Cellular senescence and brain structural changes represent defining features of aging, yet...
Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly
9 days ago
Cryo-EM structures of HSV-1 helicase-primase and replication fork complexes reveal mechanisms of...
The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism
9 days ago
Umbrella toxin particles produced by Actinobacteria contain five spokes tipped with variable...
Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain
9 days ago
The establishment of the intravital imaging of externally immobilized embryos (IMEE) method...