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Last updated 10 days ago
Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning
10 days ago
Nature Chemical Biology, Published online: 05 December 2025; doi:10.1038/s41589-025-02083-zA deep-learning-based de novo...
Configurational isomerization around the metal center underlies chemoselectivity of a radical halogenase
15 days ago
Nature Chemical Biology, Published online: 01 December 2025; doi:10.1038/s41589-025-02078-wRadical FeII/α-ketoglutarate-dependent halogenases are...
When membrane proteins prefer lipids
18 days ago
Nature Chemical Biology, Published online: 28 November 2025; doi:10.1038/s41589-025-02084-yThe function of membrane...
Mapping cellular contacts in situ
19 days ago
Nature Chemical Biology, Published online: 27 November 2025; doi:10.1038/s41589-025-02080-2A recent study developed...
Dynamic metal coordination controls chemoselectivity in a radical halogenase
25 days ago
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02077-xRadical FeII/α-ketoglutarate-dependent halogenases are...
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR–Cas system
25 days ago
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02075-zThe CorA-associated type III-B...
Acid enables biogenic crystallization
25 days ago
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02079-9How biogenic crystals form...
SINE compounds activate exportin 1 degradation through an allosteric mechanism
25 days ago
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02058-0Selinexor is a covalent...
Redirecting endogenous allies
25 days ago
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02072-2Research shows how small...
Gluing the allosteric way
25 days ago
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02059-zMolecular glue degraders induce...
Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap
28 days ago
Nature Chemical Biology, Published online: 18 November 2025; doi:10.1038/s41589-025-02076-yA multiscale photoproximity labeling...
Improving phenotypic screening
28 days ago
Nature Chemical Biology, Published online: 17 November 2025; doi:10.1038/s41589-025-02093-xImproving phenotypic screening