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Last updated 12 days ago
Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy
9 months ago
Nat Commun. 2025 Dec 16;17(1):272. doi: 10.1038/s41467-025-66976-2.ABSTRACTSpatiotemporally-controllable regulation of innate immunity in...
Dual PI3K/mTOR inhibition is required to combat resistance to CDK4/6 inhibitor and endocrine therapy in PIK3CA-mutant breast cancer
9 months ago
Sci Transl Med. 2025 Dec 17;17(829):eadp5088. doi: 10.1126/scitranslmed.adp5088. Epub 2025 Dec 17.ABSTRACTCombined...
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective
9 months ago
Sci Transl Med. 2025 Dec 17;17(829):eadv9403. doi: 10.1126/scitranslmed.adv9403. Epub 2025 Dec 17.ABSTRACTTyrosine...
SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress
9 months ago
Nat Commun. 2025 Dec 19;17(1):911. doi: 10.1038/s41467-025-67633-4.ABSTRACTRNA splicing is fundamental to cellular...
Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts
9 months ago
Sci Transl Med. 2025 Dec 24;17(830):eadx6797. doi: 10.1126/scitranslmed.adx6797. Epub 2025 Dec 24.ABSTRACTTargeting...
Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state
9 months ago
Nat Commun. 2025 Dec 15;17(1):832. doi: 10.1038/s41467-025-67169-7.ABSTRACTThe contribution of chemotherapy-induced tissue injury...
Transient hepatic reconstitution of trophic factors enhances aged immunity
9 months ago
Nature. 2026 Feb;650(8101):481-489. doi: 10.1038/s41586-025-09873-4. Epub 2025 Dec 17.ABSTRACTAgeing erodes human immunity...
Harnessing multivalency and FcγRIIB engagement to augment anti-CD27 immunotherapy
9 months ago
Nat Commun. 2025 Dec 20;17(1):1122. doi: 10.1038/s41467-025-67882-3.ABSTRACTDespite significant clinical progress, checkpoint blockade...
IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production in mice
9 months ago
Nat Commun. 2025 Dec 23;17(1):1102. doi: 10.1038/s41467-025-67867-2.ABSTRACTIL-33 is an inflammatory cytokine contributing...
GBP2 condensates promote ferroptosis to sensitize anti-PD-L1 immunotherapy in melanoma
9 months ago
Nat Commun. 2025 Dec 24;17(1):964. doi: 10.1038/s41467-025-67690-9.ABSTRACTThe mechanisms underlying the limited response...
IL-17a induces age-related olfactory dysfunction by impairing regeneration and promoting respiratory metaplasia in mice
8 months ago
Nat Commun. 2025 Dec 29;17(1):1036. doi: 10.1038/s41467-025-67786-2.ABSTRACTThe olfactory epithelium (OE) undergoes life-long...
A Plug-in system for reprogramming the editing patterns of base editors
9 months ago
Nat Commun. 2025 Dec 20;17(1):910. doi: 10.1038/s41467-025-67632-5.ABSTRACTDNA base editors are transformative genome...