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Cancer Cell
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Last updated 14 days ago
Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study
14 days ago
In a phase 1b randomized clinical trial, Wang et al. demonstrate the...
A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma
14 days ago
(Cancer Cell 16, 295–308; October 6, 2009)
CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases
14 days ago
The impact of neutrophil maturation in refractory tumors such as bone metastases...
Lymphoma accelerates T cell and tissue aging
14 days ago
Hesterberg et al. show that lymphoma provokes marked and rapid changes in...
Distinct follicular T cell subsets regulate lymphoma progression and outcomes
14 days ago
Abe et al. unveil phenotypically and spatially distinct T cell subsets that...
Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer
14 days ago
Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered...
A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
14 days ago
Feng et al. demonstrate the potent antitumor efficacy of MCB-294, a pan-KRAS...
Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
14 days ago
Xie et al. identify that Clostridium butyricum enhances anti-PD-1 efficacy in colorectal...
Cell-free DNA fragmentomics in cancer
14 days ago
The analysis of cell-free DNA (cfDNA) fragmentation patterns, known as “fragmentomics,” has...
Subclonal immune evasion in non-small cell lung cancer
14 days ago
Dijkstra et al. investigate whether individual cancer subclones differ in their immune...
A first-in-class EGFR-directed KRAS G12V selective inhibitor
14 days ago
Despite KRAS G12V being a common mutation in cancer, no direct inhibitors...
Bringing immunotherapy to clinical practice in dMMR/MSI-high colon cancer
14 days ago
Upfront resection is the standard treatment for localized dMMR/MSI-high colon cancer. In...