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Cancer Cell
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Last updated 19 days ago
Antigen-specific profiling identifies T-bet+ melanoma-specific CD8+ T cells associated with response to neoadjuvant PD-1 blockade
19 days ago
Wang et al. apply antigen-specific profiling in a neoadjuvant anti-PD-1 melanoma trial...
Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest
19 days ago
Galeano Niño et al. show that extracellular bacteria dominate colorectal and oral...
RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition
19 days ago
Diamond et al. find RAF-independent (“class III”) mutations in MEK1/2 kinases are...
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors
19 days ago
Herbrich et al. demonstrate that TET2-mutant clonal hematopoiesis improves response to immune...
Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence
19 days ago
Piyadasa et al. map proteins, genes, and glycans across a large glioma...
Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
19 days ago
Guo et al. show that anti-PD-L1 + CD40 agonist therapy activates anti-tumor...
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
19 days ago
Marteau et al. integrate colorectal cancer single-cell datasets, classify immune phenotypes, and...
Characterization of a pathogenic subpopulation of human glioma associated macrophages linked to glioma progression
19 days ago
Yu et al. identify a functionally distinct subpopulation of glioma associated macrophages...
Epitranscriptomic control of cancer hallmarks: Functions, mechanisms, and therapeutics of RNA modifications
19 days ago
RNA modifications dynamically regulate cancer hallmarks. Deng et al. summarize how epitranscriptomic...
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
19 days ago
Zhang et al. show that CRC cells adopt a Paneth-like state to...
Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications
19 days ago
Liu et al. review how spatial omics technologies reveal the organization, interaction...
Fusobacterium, quiescent niches, and therapy response in colorectal cancer
19 days ago
In this issue of Cancer Cell, Galeano Niño et al. report that...