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Cancer Cell
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Last updated 24 days ago
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target
24 days ago
Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk...
Stromal lipid species dictate melanoma metastasis and tropism
24 days ago
Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine...
Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception
24 days ago
Zhu et al. reveal coordinated interplay between innate and adaptive immunity in...
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis
24 days ago
Dang et al. report that group-3 medulloblastomas (MBs) show c-MYC-driven high DLAT...
Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts
24 days ago
Cancer patients with bone metastases often exhibit resistance to immunotherapy. Cheng et...
A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies
24 days ago
Mosialou et al. use malignant cells and osteoblasts from MDS/AML patients treated...
Spatial determinants of antibody-drug conjugate SHR-A1811 efficacy in neoadjuvant treatment for HER2-positive breast cancer
24 days ago
Ma et al. conduct a translational study on HER2+ breast cancer receiving...
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance
24 days ago
Lei et al. reveal that radiotherapy (RT) elevates mitochondrial copper and induces...
Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion
24 days ago
The overall impact of arginine metabolism in tumor progression remains unclear. Using...
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures
24 days ago
Tang et al. utilize spatial transcriptomics to identify TLSs and uncover their...
All-trans retinoic acid beyond acute promyelocytic leukemia
24 days ago
All-trans retinoic acid (ATRA), a known regulator of hematopoiesis, is a key...
TAMing immunity through an unexpected source
24 days ago
Arginine availability and metabolism critically shape tumor-immune interactions. In this issue of...