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Cancer Cell
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Last updated 7 days ago
Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma
7 days ago
Di Meo et al. demonstrate that multiple myeloma relapses after CAR T...
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
7 days ago
Cheung et al. describe efficient T cell control of nascent neoantigen+ and...
Neoadjuvant nab-paclitaxel plus gemcitabine followed by modified FOLFIRINOX for resectable pancreatic cancer: A randomized phase 3 trial
7 days ago
Bai et al. report results from a randomized phase 3 trial showing...
TROP-2-targeted antibody-drug conjugate SHR-A1921 for advanced or metastatic solid tumors: A first-in-human phase 1 study
7 days ago
Zhong et al. report that SHR-A1921, a novel TROP-2-targeted antibody-drug conjugate, demonstrates...
Remodeling of T and endothelial cells during total neoadjuvant therapy in rectal cancer
7 days ago
Gao et al. characterize the tumor microenvironment dynamics following total neoadjuvant therapy...
Restraint of cancer cell plasticity by spatial homotypic clustering
7 days ago
Migliozzi et al. use single-cell resolution spatial transcriptomics of 16 glioblastoma and...
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
7 days ago
Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across...
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
7 days ago
Ren et al. demonstrate pseudo-synaptic connections between sensory neurons and pancreatic ductal...
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
7 days ago
Taghbalout et al. apply collections of advanced multi-omics analyses to substantiate ecDNA’s...
Spatial patterns of glioblastoma
7 days ago
Glioblastoma features extensive gene expression heterogeneity and high lethality, yet the mechanisms...
Toward a new standard: Sequential multi-agent neoadjuvant chemotherapy in resectable pancreatic cancer
7 days ago
For resectable pancreatic cancer, upfront surgery followed by adjuvant therapy has long...
MED1-driven ecDNA super-enhancers in cancer
7 days ago
Extrachromosomal circular DNA (ecDNA), enriched with enhancers, drives oncogenic transcription and tumor...