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bioRxiv Subject Collection: Neuroscience

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Last updated 19 minutes ago

Discovery and Preclinical Validation of a Clinically Optimized Mitochondrial Complex I Modulator for Alzheimer's Disease

19 minutes ago

Alzheimer's disease (AD) is characterized by diminished capacity to mount adaptive cellular...

Menarche onset is an inflection point for mental health and brain development

about 1 hour ago

Menarche is a normative milestone of female puberty, yet its role in...

Sex influences gliovascular unit assembly and function in the developing mouse brain

about 1 hour ago

The gliovascular unit (GVU), a specialized interface between the brain and the...

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

about 1 hour ago

Loss of neuronal identity and metabolic dysfunction are features of Alzheimer's disease...

Mechanosensory Signaling in Axolotl Courtship and Evolution of Communication

about 1 hour ago

In behavioral biology, many models have been proposed to explain how communication...

Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors

about 1 hour ago

N-methyl-D-aspartate receptors (NMDARs) mediate excitatory signaling essential for synaptic plasticity and memory...

Path Integration and Spatial Updating Recruit Distinct Cognitive-Neural Mechanisms in Humans

about 2 hours ago

Path integration and spatial updating refer to the integration of self-motion information...

The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders

about 2 hours ago

Background Perinatal mood and anxiety disorders (PMADs) are among the most common...

A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use

about 2 hours ago

Organisms must regulate metabolic resources such as oxygen (O2) and nutrients despite...

Serotonergic innervation and cortical progenitor regulation in human brain assembloids

about 2 hours ago

Neuromodulatory signaling is classically associated with mature neural circuits, yet serotonergic projections...

Time-resolved hemodynamic responses to sentence-level speech perception, production, and self-monitoring

about 2 hours ago

Functional magnetic resonance imaging (fMRI) has been widely utilized to explore the...

A defined 2D system for generating and expanding human basal radial glia from iPSCs

about 6 hours ago

Basal radial glia (bRG) drive human cortical expansion but remain underrepresented in...