Most Recent Articles: Trials

Internet of Things-based pulsed electromagnetic field combined with exercise therapy in patients with knee osteoarthritis: randomized, controlled, noninferiority trial protocol

10 months ago

Knee osteoarthritis (KOA) is a chronic musculoskeletal condition that affects the entire...

Mental health first aid training to improve depression literacy among health ambassadors in Iran: study protocol for a cluster-randomized controlled trial

10 months ago

One of the strategies for enhancing the mental health literacy of the...

Estimating treatment effect in randomised controlled trials with continuous outcomes subject to non-compliance: a logistic regression-based multiple imputation approach

10 months ago

Non-compliance in randomised controlled trials poses a significant challenge to accurately estimate...

Extended mesenteric resection in Crohn’s disease: EXCEED Study Protocol—a blinded multicenter randomized controlled clinical trial (RCT)

10 months ago

Crohn’s disease presents a persistent challenge, particularly concerning disease recurrence in patients...

Ivabradine for prevention of myocardial injury after noncardiac surgery (PREVENT-MINS trial): study protocol for a randomized controlled trial

10 months ago

Myocardial injury is a major cause of death after noncardiac surgery and...

Comparison of 90-90 ball and balloon exercise versus Kegel’s exercise on pelvic floor muscle strength and quality of life among postpartum women with stress urinary incontinence—a randomized clinical trial protocol

10 months ago

Stress urinary incontinence (SUI) is one of the notable problems in postpartum...

Correction: Development of a core outcome set for paediatric upper limb spasticity; a structured review protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey

10 months ago

The effect of Trehalose on inflammatory markers, oxidative stress, clinical symptoms, and mortality in patients with head trauma in Iran: a double-blind, placebo-controlled, randomized clinical trial protocol

10 months ago

The occurrence of traumatic brain injury (TBI) has been progressively increasing over...

Correction: Elucidating treatment targets and mediators within a confirmatory efficacy trial: study protocol for a randomized controlled trial of cognitive-behavioral therapy vs. light therapy for winter depression

10 months ago

Effects of a theory-driven, disclosure-based family support programme on fear of cancer recurrence for couples coping with breast cancer: protocol for a multi-centre randomised controlled trial

10 months ago

Breast cancer incidence in women is increasing, although the survival rate remains...

Supplemental choline to prevent and treat learning and memory deficits of early-life iron deficiency (The SupCHO Study): study protocol for a randomized, placebo-controlled trial in Ugandan infants with iron deficiency anemia

10 months ago

Iron deficiency (ID) limits the neurodevelopmental potential of more than 200 million...

Increasing measles vaccination coverage through supplementation with an SQ-LNS incentive in children aged 6 to 23 months: study protocol of NutriVax-Measles, a superiority pragmatic parallel cluster-randomized controlled trial in Yobe State, Northern Nige

10 months ago

Undernutrition and infectious diseases form a vicious cycle that poses a dual...