Most Recent Articles: Trials

Internet of Things-based pulsed electromagnetic field combined with exercise therapy in patients with knee osteoarthritis: randomized, controlled, noninferiority trial protocol

8 months ago

Knee osteoarthritis (KOA) is a chronic musculoskeletal condition that affects the entire...

Mental health first aid training to improve depression literacy among health ambassadors in Iran: study protocol for a cluster-randomized controlled trial

8 months ago

One of the strategies for enhancing the mental health literacy of the...

Estimating treatment effect in randomised controlled trials with continuous outcomes subject to non-compliance: a logistic regression-based multiple imputation approach

8 months ago

Non-compliance in randomised controlled trials poses a significant challenge to accurately estimate...

Extended mesenteric resection in Crohn’s disease: EXCEED Study Protocol—a blinded multicenter randomized controlled clinical trial (RCT)

8 months ago

Crohn’s disease presents a persistent challenge, particularly concerning disease recurrence in patients...

Ivabradine for prevention of myocardial injury after noncardiac surgery (PREVENT-MINS trial): study protocol for a randomized controlled trial

8 months ago

Myocardial injury is a major cause of death after noncardiac surgery and...

Comparison of 90-90 ball and balloon exercise versus Kegel’s exercise on pelvic floor muscle strength and quality of life among postpartum women with stress urinary incontinence—a randomized clinical trial protocol

8 months ago

Stress urinary incontinence (SUI) is one of the notable problems in postpartum...

Correction: Development of a core outcome set for paediatric upper limb spasticity; a structured review protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey

8 months ago

The effect of Trehalose on inflammatory markers, oxidative stress, clinical symptoms, and mortality in patients with head trauma in Iran: a double-blind, placebo-controlled, randomized clinical trial protocol

8 months ago

The occurrence of traumatic brain injury (TBI) has been progressively increasing over...

Correction: Elucidating treatment targets and mediators within a confirmatory efficacy trial: study protocol for a randomized controlled trial of cognitive-behavioral therapy vs. light therapy for winter depression

8 months ago

Effects of a theory-driven, disclosure-based family support programme on fear of cancer recurrence for couples coping with breast cancer: protocol for a multi-centre randomised controlled trial

8 months ago

Breast cancer incidence in women is increasing, although the survival rate remains...

Supplemental choline to prevent and treat learning and memory deficits of early-life iron deficiency (The SupCHO Study): study protocol for a randomized, placebo-controlled trial in Ugandan infants with iron deficiency anemia

8 months ago

Iron deficiency (ID) limits the neurodevelopmental potential of more than 200 million...

Increasing measles vaccination coverage through supplementation with an SQ-LNS incentive in children aged 6 to 23 months: study protocol of NutriVax-Measles, a superiority pragmatic parallel cluster-randomized controlled trial in Yobe State, Northern Nige

8 months ago

Undernutrition and infectious diseases form a vicious cycle that poses a dual...