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Most Recent Articles: Genome Medicine
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Last updated 8 months ago
Genetic atlas of plasma metabolome across 40 human common diseases: mapping causal metabolites to disease risk
8 months ago
Metabolites are closely linked to individual health and disease conditions. Identifying genetic...
A comprehensive long-read sequencing system to assess DNA methylation at differentially methylated regions and imprinting-disorder-related genes
8 months ago
Imprinted genes are expressed in a parental-origin–specific manner. The imprinted regions including...
Development of a consensus molecular classifier for pancreatic ductal adenocarcinoma
8 months ago
Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge, with a 5-year survival...
Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia
8 months ago
Tuberculosis (TB) remains a major public health concern. Improving TB control programs...
PredIG: an interpretable predictor of T-cell epitope immunogenicity
8 months ago
Cytotoxic T cells are key effectors in the immune response against pathogens...
Exploring the size limits of Bionano optical genome mapping to resolve alternative structures of linked interspersed chromosomal duplications
8 months ago
Determining the correct structure of large, interspersed duplications and related complex genomic...
Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients
9 months ago
Type 1 autoimmune pancreatitis (AIP) is pancreatic manifestation of IgG4-related disease (IgG4-RD)...
Genome instability and crosstalk with the immune response
9 months ago
Genome instability, tumour-promoting inflammation, and immune escape are three distinct hallmarks of...
Spatial-reprogramming derived GPNMB+ macrophages interact with COL6A3+ fibroblasts to enhance vascular fibrosis in glioblastoma
9 months ago
Neoadjuvant therapy plays an important role in the treatment of glioblastoma (GBM)...
Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits
9 months ago
A comprehensive and representative reference database is crucial for accurate taxonomic and...
Investigating the interplay between prematurity and genetic variation in the context of rare developmental disorders
9 months ago
Rare damaging genetic variation accounts for a substantial proportion of the risk...
Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
9 months ago
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML)...