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Most Recent Articles: Genome Medicine
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Last updated 10 months ago
Genetic atlas of plasma metabolome across 40 human common diseases: mapping causal metabolites to disease risk
10 months ago
Metabolites are closely linked to individual health and disease conditions. Identifying genetic...
A comprehensive long-read sequencing system to assess DNA methylation at differentially methylated regions and imprinting-disorder-related genes
10 months ago
Imprinted genes are expressed in a parental-origin–specific manner. The imprinted regions including...
Development of a consensus molecular classifier for pancreatic ductal adenocarcinoma
10 months ago
Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge, with a 5-year survival...
Clinical and bacterial determinants of unfavorable tuberculosis treatment outcomes: an observational study in Georgia
10 months ago
Tuberculosis (TB) remains a major public health concern. Improving TB control programs...
PredIG: an interpretable predictor of T-cell epitope immunogenicity
10 months ago
Cytotoxic T cells are key effectors in the immune response against pathogens...
Exploring the size limits of Bionano optical genome mapping to resolve alternative structures of linked interspersed chromosomal duplications
10 months ago
Determining the correct structure of large, interspersed duplications and related complex genomic...
Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients
10 months ago
Type 1 autoimmune pancreatitis (AIP) is pancreatic manifestation of IgG4-related disease (IgG4-RD)...
Genome instability and crosstalk with the immune response
10 months ago
Genome instability, tumour-promoting inflammation, and immune escape are three distinct hallmarks of...
Spatial-reprogramming derived GPNMB+ macrophages interact with COL6A3+ fibroblasts to enhance vascular fibrosis in glioblastoma
10 months ago
Neoadjuvant therapy plays an important role in the treatment of glioblastoma (GBM)...
Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits
10 months ago
A comprehensive and representative reference database is crucial for accurate taxonomic and...
Investigating the interplay between prematurity and genetic variation in the context of rare developmental disorders
10 months ago
Rare damaging genetic variation accounts for a substantial proportion of the risk...
Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
10 months ago
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML)...