Angewandte Chemie International Edition

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

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Ribozymes are powerful tools for site-specific RNA modification. Their activities range from...

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

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The human metabolism has been investigated for several millennia. The metabolome is...

Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction

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We introduce cell-penetrating peptides (CPPs) with polyfluoroalkyl-tags that drastically enhance intracellular protein...

Mapping the Reactivity of the C═C Bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals

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Endo or Exo? The first quantitative kinetic mapping of the nucleophilic reactivity...

Inside Front Cover: Enhancing Superlubricity and Wear Resistance in Mechanically Robust Hydrogel via Microliter‐Scale Subsurface‐Initiated Polymer Brush Grafting (Angew. Chem. Int. Ed. 23/2026)

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Articular cartilage features a hierarchical biphasic structure, exhibiting exceptional load-bearing capacity and...

Concerted Proton and Electron Transfer in Heterogeneous Electrocatalytic CO2 Reduction

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Concerted proton-electron transfer (CPET) enables CO2-to-CO conversion with significantly reduced energy cost...

Inside Back Cover: Mapping the Reactivity of the C═C Bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals (Angew. Chem. Int. Ed. 23/2026)

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Which factors control the nucleophilicity of endo- and exo-glycals? Kinetic studies combined...

Petra Utroša

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“My long-term goal is to be a good scientist… Chemistry/science is fun...

Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

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The use of transition-metal catalysts and design of chiral ligands have allowed...

Correction to “Toward Ultra‐High‐Quality‐Factor Wireless Masing Magnetic Resonance Sensing”

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Outside Back Cover: Domino Polymerization for the Synthesis of Reductively Degradable Poly(disulfide)s With Arbitrary Side‐Chain Structures (Angew. Chem. Int. Ed. 23/2026)

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In Research Article e24666, Yukiya Kitayama and co-workers report a novel domino...

Outside Front Cover: Polyfluoroalkyl‐Tagged Cell‐Penetrating Peptide‐Additives Enhance Intracellular Protein Delivery via Sustained Monomeric Lipid Interaction (Angew. Chem. Int. Ed. 23/2026)

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Efficient delivery of proteins into cells remains a major challenge in biomedical...