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Journal of Medicinal Chemistry: Latest Articles (ACS Publications)
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Last updated about 16 hours ago
[ASAP] Discovery of 2-Amino-7-Amide Quinazoline Derivatives as Potent and Orally Bioavailable Inhibitors Targeting Extracellular Signal-Regulated Kinase 1/2
about 10 hours ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c01055
[ASAP] Self-Assembly of Ru3-Aptamer Nanoparticles Triggers Pyroptosis through Photoredox Catalysis of NADH and Lysosomal Disruption
about 17 hours ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00022
[ASAP] Design, Synthesis, and Biological Evaluation of 4-(Difluoromethyl)-1H-imidazole-5-carboxylic Acids/4-(3-Cyanophenoxy)pyrimidine-5-carboxylic Acids as P2Y1 Receptor Antagonists for Ischemic Stroke Treatment
about 17 hours ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.4c03117
[ASAP] Optimization, Immunological Evaluation, and Combination Study of Mincle-Dependent Self-Adjuvanted Anti-Tn Cancer Vaccines with an External Adjuvant
about 21 hours ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00522
[ASAP] Selective, Non-nucleotidic Radiotracer for P2Y12 Receptors: Design, Synthesis, Characterization, and Imaging of Brain Slices
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00213
[ASAP] Explainable Machine Learning for ETR and Drug Chameleonicity
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00536
[ASAP] Discovery of Imidazo[1,2-b]pyridazine Derivatives as Potent and Highly Selective Irreversible Bruton’s Tyrosine Kinase (BTK) Inhibitors
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.4c03083
[ASAP] XPO1-Targeting Selective Inhibitors of Transcriptional Activation Suppress Graft-versus-Host Disease
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00989
[ASAP] Improve the Stability and Activity of Antimicrobial Peptides by the Proline-Based PXXP Hinge Structure
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00364
[ASAP] Discovery and Characterization of PVTX-321 as a Potent and Orally Bioavailable Estrogen Receptor Degrader for ER+/HER2– Breast Cancer
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00223
[ASAP] Diazepine Agonists of the 5-HT2C Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352)
1 day ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.4c02923
[ASAP] Self-Assembly versus Coassembly: An Amphiphilic NIR-II Aggregation-Induced Emission Luminogen for Phototheranostics of Orthotopic Glioblastoma
2 days ago
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5c00590