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Last updated 4 days ago
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene | Science Translational Medicine
4 days ago
Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice.
Intestinal epithelium–derived IL-34 reprograms macrophages to mitigate gastrointestinal tract graft-versus-host disease | Science Translational Medicine
4 days ago
Intestinal epithelium–derived IL-34 regulates macrophage polarization in an apolipoprotein E–dependent manner and...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine
4 days ago
A high-throughput, noninvasive, rapid protease-activated nanosensor identifies patients with pancreatic cancer in...
Coactivation of innate immune suppressive cells induces acquired resistance against combined TLR agonism and PD-1 blockade | Science Translational Medicine
4 days ago
Activation of innate immune suppressive cells drives acquired resistance to Toll-like receptor...
Tumor extracellular vesicle–derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming | Science Translational Medicine
4 days ago
PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism.
Antisense oligonucleotide–mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington’s disease iPSC–derived striatal neurons | Science Translational Medicine
4 days ago
MSH3 lowering by antisense oligonucleotides dose-dependently reduces CAG repeat expansions in iPSC-derived...
Pseudomonas aeruginosa infection induces intragraft lymphocytotoxicity that triggers lung transplant antibody-mediated rejection | Science Translational Medicine
11 days ago
P. aeruginosa causes antibody-mediated rejection in lung allografts that can be prevented...
Selection and prioritization of candidate combination regimens for the treatment of tuberculosis | Science Translational Medicine
11 days ago
Mathematical modeling of relapse data predicts tuberculosis drug regimens, identifying short, potential...
Translocating gut pathobiont Enterococcus gallinarum induces TH17 and IgG3 anti-RNA–directed autoimmunity in mouse and human | Science Translational Medicine
11 days ago
Translocating pathobiont Enterococcus gallinarum promotes human TH17 and anti-RNA IgG3 autoantibody responses...
Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor–resistant NRAS-mutant melanoma | Science Translational Medicine
11 days ago
S6 kinase 2 is a vulnerability in mitogen-activated protein kinase inhibitor–resistant NRAS-mutant...
No tolerance for Pseudomonas in lung transplants | Science Translational Medicine
11 days ago
Pseudomonas infection after lung transplantation induces acute intragraft lymphocytotoxicity that promotes antibody-mediated...
Proteomic analysis reveals distinct cerebrospinal fluid signatures across genetic frontotemporal dementia subtypes | Science Translational Medicine
11 days ago
Both distinct and common cerebrospinal fluid proteomic signatures were observed in the...