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Last updated 9 days ago
SnapShot: Targeted protein degradation
9 days ago
Targeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate...
Pervasive mislocalization of pathogenic coding variants underlying human disorders
9 days ago
Pathogenic missense variation can affect protein function in many ways, but the...
A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors
9 days ago
Zebrahub is a comprehensive web-based atlas integrating spatiotemporal and transcriptional data at...
Saturation mutagenesis-reinforced functional assays for disease-related genes
9 days ago
Saturation mutagenesis-reinforced functional assays (SMuRF) is a cost-effective, broadly implementable deep mutational...
Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues
9 days ago
Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA...
Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy
9 days ago
A DMD rhesus monkey model exhibits profound changes in immune cells, fibro-adipogenic...
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders
9 days ago
ARC-SV enables highly accurate detection and characterization of localized complex rearrangements of...
The TMEM132B-GABAA receptor complex controls alcohol actions in the brain
9 days ago
Identification of TMEM132B as a GABAAR auxiliary subunit that modulates alcohol action...
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis
9 days ago
We find that when disseminated breast cancer cells enter the lung, embryo-derived...
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
9 days ago
Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+...
mTOR activity paces human blastocyst stage developmental progression
9 days ago
The timing of human blastoid post-implantation development can be paced down by...
Private information leakage from single-cell count matrices
9 days ago
This study demonstrates that single-cell RNA sequencing count matrices, although valuable for...