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Last updated about 23 hours ago
Scaling a foundational protein language model to 100 billion parameters
about 23 hours ago
Nature Methods, Published online: 03 April 2025; doi:10.1038/s41592-025-02637-yxTrimoPGLM, a protein language model...
xTrimoPGLM: unified 100-billion-parameter pretrained transformer for deciphering the language of proteins
about 23 hours ago
Nature Methods, Published online: 03 April 2025; doi:10.1038/s41592-025-02636-zxTrimo protein general language model...
Life beyond labels
2 days ago
Nature Methods, Published online: 02 April 2025; doi:10.1038/s41592-025-02649-8Advances in label-free microscopy allow...
The need to implement FAIR principles in biomolecular simulations
2 days ago
Nature Methods, Published online: 02 April 2025; doi:10.1038/s41592-025-02635-0In the Big Data era...
Sharing data from the Human Tumor Atlas Network through standards, infrastructure and community engagement
4 days ago
Nature Methods, Published online: 31 March 2025; doi:10.1038/s41592-025-02643-0This Perspective outlines the datasets...
Uncalled4 improves nanopore DNA and RNA modification detection via fast and accurate signal alignment
7 days ago
Nature Methods, Published online: 28 March 2025; doi:10.1038/s41592-025-02631-4Uncalled4 is a toolkit for...
Denoising Search doubles the number of metabolite and exposome annotations in human plasma using an Orbitrap Astral mass spectrometer
7 days ago
Nature Methods, Published online: 28 March 2025; doi:10.1038/s41592-025-02646-xSpectral Denoising removes chemical and...
Atomic context-conditioned protein sequence design using LigandMPNN
7 days ago
Nature Methods, Published online: 28 March 2025; doi:10.1038/s41592-025-02626-1LigandMPNN is a deep-learning-based protein...
Enabling global image data sharing in the life sciences
7 days ago
Nature Methods, Published online: 28 March 2025; doi:10.1038/s41592-024-02585-zThis Perspective provides a roadmap...
Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability
11 days ago
Nature Methods, Published online: 24 March 2025; doi:10.1038/s41592-025-02632-3This work presents an in...
Simultaneous single-cell DNA damage profiling and RNA sequencing by Paired-Damage-seq
11 days ago
Nature Methods, Published online: 24 March 2025; doi:10.1038/s41592-025-02634-1We developed Paired-Damage-seq to profile...
Connectivity of single neurons classifies cell subtypes in mouse brains
14 days ago
Nature Methods, Published online: 21 March 2025; doi:10.1038/s41592-025-02621-6This Resource presents a method...