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Last updated 3 days ago
Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth | Science Translational Medicine
3 days ago
Mouse models of papillary craniopharyngioma enable drug screening and reveal that hypothalamic...
IFN-γ–producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren’s disease | Science Translational Medicine
3 days ago
Treg cell–specific deletion of Ca2+ influx results in a Sjögren’s disease–like phenotype...
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans | Science Translational Medicine
3 days ago
Developing an animal model of human brain stimulation therapy reveals that striatal...
Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis | Science Translational Medicine
3 days ago
Dextromethorphan inhibits secretion of collagens, latent TGF-β–binding proteins (LTBP1 and LTBP2), and...
An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus | Science Translational Medicine
3 days ago
A(H5N1) mRNA vaccines elicited neutralizing antibodies against 2.3.4.4b HPAI isolates from 2022...
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron | Science Translational Medicine
3 days ago
Studies reveal pharmacological characteristics for activating the GLP-1 receptor with a nonpeptide...
Development of a fibrin-targeted theranostic for gastric cancer | Science Translational Medicine
10 days ago
Fibrin within the tumor can be used as a target for the...
Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity | Science Translational Medicine
10 days ago
Sensitization of the keratinocyte mechanotransducer PIEZO1 contributes to paclitaxel-induced touch pain.
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes | Science Translational Medicine
10 days ago
ATP citrate lyase is a target for therapeutic interventions in pulmonary hypertension...
ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools | Science Translational Medicine
10 days ago
This study uncovers a pathway controlling fatty acid distribution in adipose tissue...
Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation | Science Translational Medicine
10 days ago
Computational and molecular analysis identified benzamil as a potential treatment for skin...
Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation | Science Translational Medicine
10 days ago
Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation...