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Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis | Science Translational Medicine
1 day ago
The chemokine receptor 5 antagonist maraviroc attenuates EAE pathogenesis in mouse models...
Clinically compliant enrichment of human pluripotent stem cell–derived islets | Science Translational Medicine
1 day ago
Stem cell–derived islets can be enriched by density gradient separation.
Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial | Science Translational Medicine
1 day ago
In a randomized, placebo-controlled clinical trial, mavoglurant reduced cocaine and alcohol use...
Ebola virus vaccination elicits Ebola virus–specific immune responses without substantial cross-reactivity to other filoviruses | Science Translational Medicine
1 day ago
The Ad26/MVA Ebola virus vaccine elicited coordinated antibody and T cell responses...
Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome | Science Translational Medicine
1 day ago
A gene therapy construct for Rett syndrome includes a self-regulating, miRNA-based feed-forward...
Path to a cure for debilitating pregnancy sickness | Science Translational Medicine
1 day ago
Identification of GDF15 as a cause of severe nausea and vomiting during...
Human iPSC–derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models | Science Translational Medicine
1 day ago
Expanded human iPSC–derived nephron progenitor cells secrete renoprotective factors that have therapeutic...
Identification and characterization of human retinal stem cells capable of retinal regeneration | Science Translational Medicine
8 days ago
Human neural retinal stem-like cells (hNRSCs) found in fetal retinas and organoids...
Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans | Science Translational Medicine
8 days ago
Comprehensive profiling of Ixodes scapularis antigens reveals that tick bites induce antivector...
Variant screening of PYY3–36 leads to potent long-acting PYY analogs with superior Y2 receptor selectivity | Science Translational Medicine
8 days ago
A Y2 receptor–selective and long-acting PYY derivative improves weight loss and glucose...
TRIM15 drives chondrocyte senescence and osteoarthritis progression | Science Translational Medicine
8 days ago
TRIM15 promotes chondrocyte senescence and osteoarthritis progression by mediating K48-linked ubiquitination and...
Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone | Science Translational Medicine
8 days ago
Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine...