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Last updated 2 days ago
Base-modified nucleotides mediate immune signaling in bacteria | Science
2 days ago
Signaling from pathogen sensing to effector activation is a fundamental principle of...
Deep-tissue transcriptomics and subcellular imaging at high spatial resolution | Science
2 days ago
Limited color channels in fluorescence microscopy have long constrained spatial analysis in...
Computational design of serine hydrolases | Science
9 days ago
The design of enzymes with complex active sites that mediate multistep reactions...
A direct hit | Science
11 days ago
Late last week, the Trump administration set off a frenzy in the...
Protein codes promote selective subcellular compartmentalization | Science
16 days ago
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular...
Hidden cascades of seismic ice stream deformation | Science
16 days ago
Ice streams are major regulators of sea level change. However, standard viscous...
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues | Science
16 days ago
Mitochondrial damage is a hallmark of metabolic diseases, including diabetes, yet the...
Structural pathway for PI3-kinase regulation by VPS15 in autophagy | Science
16 days ago
The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and -C2)...
Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival | Science
23 days ago
Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different...
The Sikkim flood of October 2023: Drivers, causes and impacts of a multihazard cascade | Science
23 days ago
On 3 October 2023, a multihazard cascade in the Sikkim Himalaya, India...
CASTER: Direct species tree inference from whole-genome alignments | Science
about 1 month ago
Genomes contain mosaics of discordant evolutionary histories, challenging the accurate inference of...
A world less safe and secure | Science
about 1 month ago
On 20 January, President Trump announced the withdrawal of the United States...