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Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging | Science Advances
1 day ago
Abstract Decline of mitochondrial respiratory chain (mtRC) capacity is a hallmark of...
A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses | Science Advances
1 day ago
Abstract Most mosquito-transmitted alphaviruses encode a premature opal termination codon upstream of...
Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity | Science Advances
1 day ago
Abstract Age-associated B cells (ABCs) with autoreactive properties accumulate with age and...
Discovery of a high-velocity cloud of the Milky Way as a potential dark galaxy | Science Advances
1 day ago
Abstract High-velocity clouds (HVCs) are composed of neutral hydrogen (H I) moving...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances
1 day ago
Abstract Protein- and RNA-rich bodies contribute to the spatial organization of gene...
Local suppression by link rewiring reveals discontinuous percolation transitions | Science Advances
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Abstract When a governor occupies links one by one to globally suppress...
Dihydroxyacetone phosphate generated in the chloroplast mediates the activation of TOR by CO2 and light | Science Advances
1 day ago
Abstract Light and CO 2 assimilation activate the target of rapamycin (TOR)...
Reciprocal phosphorylation between SOAK1 and SOBIR1 fine-tunes receptor-like protein (RLP)–mediated plant immunity | Science Advances
1 day ago
Abstract SUPPRESSOR OF BIR1-1 (SOBIR1) is a receptor-like kinase (RLK) that acts...
Inefficient melt mixing below a fast-spreading ridge revealed by Hess Deep lower gabbros (ODP Leg 147 and IODP Expedition 345) | Science Advances
1 day ago
Abstract The oceanic crust crystallizes from melts formed within a heterogeneous mantle...
Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets | Science Advances
1 day ago
Abstract In schizophrenia, anterior hippocampus (aHipp) overactivity is associated with orbitofrontal cortex...
Statistical analysis of fluorescence intensity transients with Bayesian methods | Science Advances
1 day ago
Abstract Molecular movement and interactions at the single-molecule level, particularly in live...
Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development | Science Advances
1 day ago
Abstract More than 60% of pregnancy losses occur during the first trimester,...