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Last updated 3 days ago

β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome | Science Translational Medicine

3 days ago

β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition...

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma | Science Translational Medicine

3 days ago

In patients with glioblastoma, navtemadlin resistance is not mediated by TP53-inactivating mutations...

Dysfunctional CD11c−CD21− extrafollicular memory B cells are enriched in the periphery and tumors of patients with cancer | Science Translational Medicine

3 days ago

Tumor-associated extrafollicular B cells are phenotypically, locationally, and functionally distinct from germinal...

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread | Science Translational Medicine

3 days ago

Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo...

Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model | Science Translational Medicine

3 days ago

Mechanotransduction inhibition yields porcine and human skin wound regeneration by altering fibroblast...

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene | Science Translational Medicine

10 days ago

Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice.

Intestinal epithelium–derived IL-34 reprograms macrophages to mitigate gastrointestinal tract graft-versus-host disease | Science Translational Medicine

10 days ago

Intestinal epithelium–derived IL-34 regulates macrophage polarization in an apolipoprotein E–dependent manner and...

Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine

10 days ago

A high-throughput, noninvasive, rapid protease-activated nanosensor identifies patients with pancreatic cancer in...

Coactivation of innate immune suppressive cells induces acquired resistance against combined TLR agonism and PD-1 blockade | Science Translational Medicine

10 days ago

Activation of innate immune suppressive cells drives acquired resistance to Toll-like receptor...

Tumor extracellular vesicle–derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming | Science Translational Medicine

10 days ago

PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism.