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Last updated 2 days ago
Reduction of prolonged excitatory neuron swelling after spinal cord injury improves locomotor recovery in mice | Science Translational Medicine
2 days ago
Reducing excitatory neuron swelling improved locomotor functional recovery after spinal cord injury...
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose | Science Translational Medicine
2 days ago
Inhibition of CYP1B1 in HSCs and trehalose/lactotrehalose dosing show preclinical antifibrotic effects...
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models | Science Translational Medicine
2 days ago
Spermidine is essential for the function of leukemia stem and progenitor cells...
B cells drive neuropathic pain–related behaviors in mice through IgG–Fc gamma receptor signaling | Science Translational Medicine
2 days ago
Nerve injury promotes IgG secretion from B cells, activating Fc gamma receptors...
Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test | Science Translational Medicine
2 days ago
Neutrophil extracellular traps are present in the urinary tract, help prevent ascending...
Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis | Science Translational Medicine
2 days ago
Scientific and clinical advances have expanded our ability to understand, prevent, and...
Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis | Science Translational Medicine
9 days ago
Antibody profiling and machine learning provide insight into the underlying pathophysiology of...
Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade | Science Translational Medicine
9 days ago
Radiation dose heterogeneity promotes systemic antitumor immunity through induction of diverse immune...
Preschool-age children maintain a distinct memory CD4+ T cell and memory B cell response after SARS-CoV-2 infection | Science Translational Medicine
9 days ago
Preschool-age children mount a different adaptive immune response to SARS-CoV-2 than adults.
Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans | Science Translational Medicine
9 days ago
Ultrasound perfusion metrics are correlated with acute spinal cord injury severity in...
A deep intronic splice–altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion | Science Translational Medicine
9 days ago
An extrathymic AIRE expression system uncovered a deep intronic AIRE variant that...
ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome | Science Translational Medicine
9 days ago
ARGX-119 is a first-in-class MuSK agonist monoclonal antibody in clinical development for...