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Last updated 9 days ago
Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster
9 days ago
Neurotransmitter identities are predicted directly from electron micrographs with high fidelity across...
The phosphorylation landscape of infection-related development by the rice blast fungus
9 days ago
A comprehensive phosphoproteomic analysis of infection-related development by a pathogenic fungus that...
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration
9 days ago
Oligodendrocytes in multiple sclerosis lesions exhibit epigenetic silencing that precludes myelin restoration...
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
9 days ago
DrugMap serves as a roadmap to develop covalent ligands for oncogenic drivers.
Tracing the origin of alveolar stem cells in lung repair and regeneration
9 days ago
Using dual recombinase-mediated intersectional genetic approaches, Liu et al. find that alveolar...
RNA aggregates harness the danger response for potent cancer immunotherapy
9 days ago
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine...
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
9 days ago
Robust and scalable iPSC-derived human neurons are generated to model 4R tauopathy...
Integrative spatial analysis reveals a multi-layered organization of glioblastoma
9 days ago
Spatial mapping shows that glioblastoma consists of both disorganized and structured regions...
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
9 days ago
Prime editing exhibits strong, chromatin-related position effects and is promoted by active...
Analysis of 3D pathology samples using weakly supervised AI
9 days ago
Patient prognostication based on 3D pathology yields superior performance to traditional 2D...
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
9 days ago
Brown fat contributes to systemic glucose homeostasis by providing BCAA-nitrogen-derived metabolites, including...
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
9 days ago
Zong et al. identified the tumor-derived L-lactate as a natural suppressor of...