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Last updated 10 days ago
SnapShot: Targeted protein degradation
10 days ago
Targeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate...
Pervasive mislocalization of pathogenic coding variants underlying human disorders
10 days ago
Pathogenic missense variation can affect protein function in many ways, but the...
A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors
10 days ago
Zebrahub is a comprehensive web-based atlas integrating spatiotemporal and transcriptional data at...
Saturation mutagenesis-reinforced functional assays for disease-related genes
10 days ago
Saturation mutagenesis-reinforced functional assays (SMuRF) is a cost-effective, broadly implementable deep mutational...
Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues
10 days ago
Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA...
Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy
10 days ago
A DMD rhesus monkey model exhibits profound changes in immune cells, fibro-adipogenic...
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders
10 days ago
ARC-SV enables highly accurate detection and characterization of localized complex rearrangements of...
The TMEM132B-GABAA receptor complex controls alcohol actions in the brain
10 days ago
Identification of TMEM132B as a GABAAR auxiliary subunit that modulates alcohol action...
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis
10 days ago
We find that when disseminated breast cancer cells enter the lung, embryo-derived...
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
10 days ago
Transfer of mitochondria via nanotubes from bone marrow stem cells to CD8+...
mTOR activity paces human blastocyst stage developmental progression
10 days ago
The timing of human blastoid post-implantation development can be paced down by...
Private information leakage from single-cell count matrices
10 days ago
This study demonstrates that single-cell RNA sequencing count matrices, although valuable for...