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Last updated 5 days ago

Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

5 days ago

Nature Methods, Published online: 11 April 2025; doi:10.1038/s41592-025-02648-9This work integrates duplex sequencing...

Perturb-tracing enables high-content screening of multi-scale 3D genome regulators

6 days ago

Nature Methods, Published online: 10 April 2025; doi:10.1038/s41592-025-02652-zThis work presents Perturb-tracing, integrating...

PTM-Mamba: a PTM-aware protein language model with bidirectional gated Mamba blocks

6 days ago

Nature Methods, Published online: 10 April 2025; doi:10.1038/s41592-025-02656-9PTM-Mamba is a post-translational modification-aware...

Computer vision for primate behavior analysis in the wild

6 days ago

Nature Methods, Published online: 10 April 2025; doi:10.1038/s41592-025-02653-yIn this Perspective, Vogg et...

Pooled CRISPR screening with optical sequencing reveals regulators of 3D chromatin organization

6 days ago

Nature Methods, Published online: 10 April 2025; doi:10.1038/s41592-025-02633-2The Perturb-Tracing approach represents a...

CAVE: Connectome Annotation Versioning Engine

7 days ago

Nature Methods, Published online: 09 April 2025; doi:10.1038/s41592-024-02426-zThe Connectome Annotation Versioning Engine...

CRISPR–Csm guided RNA imaging

7 days ago

Nature Methods, Published online: 09 April 2025; doi:10.1038/s41592-025-02672-9CRISPR RNA-targeting tools enable the...

Efficient and robust search of microbial genomes via phylogenetic compression

7 days ago

Nature Methods, Published online: 09 April 2025; doi:10.1038/s41592-025-02625-2Phylogenetic compression achieves performant and...

The big picture in science

7 days ago

Nature Methods, Published online: 09 April 2025; doi:10.1038/s41592-025-02679-2Basic science and methods development...

Understanding protein subcellular compartmentalization signals

7 days ago

Nature Methods, Published online: 09 April 2025; doi:10.1038/s41592-025-02674-7Understanding protein subcellular compartmentalization signals

Learning the immunological repertoire

7 days ago

Nature Methods, Published online: 09 April 2025; doi:10.1038/s41592-025-02673-8Learning the immunological repertoire

Scaling a foundational protein language model to 100 billion parameters

13 days ago

Nature Methods, Published online: 03 April 2025; doi:10.1038/s41592-025-02637-yxTrimoPGLM, a protein language model...